6-AMINOPYRIMIDIN-2(1H)-ONE HYDROCHLORIDE

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Names

[ CAS No. ]:
6047-01-4

[ Name ]:
6-AMINOPYRIMIDIN-2(1H)-ONE HYDROCHLORIDE

[Synonym ]:
6-Aminopyrimidin-2(1H)-one hydrochloride
1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[1,2-a][1,5]diazocin-8-one,monohydrochloride
(+/-)-cytisine hydrochloride
1,2,3,4,5,6-Hexahydro-1,5-methano-pyrido[1,2-a][1,5]diazocin-8-on,Monohydrochlorid

Chemical & Physical Properties

[ Boiling Point ]:
218ºC at 2 MM HG

[ Melting Point ]:
152-153ºC

[ Molecular Formula ]:
C4H6ClN3O

[ Molecular Weight ]:
147.56300

[ Exact Mass ]:
147.02000

[ PSA ]:
71.77000

[ LogP ]:
0.73530

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HA4200000
CHEMICAL NAME :
Cytisine hydrochloride
CAS REGISTRY NUMBER :
6047-01-4
LAST UPDATED :
199109
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C11-H14-N2-O.Cl-H
MOLECULAR WEIGHT :
226.73
WISWESSER LINE NOTATION :
T C666 A GVN LM&TTJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9400 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
REFERENCE :
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 35,161,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1730 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
REFERENCE :
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 35,161,1969

Safety Information

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (1R,9S)-N-benzyl cytisine
  • 11-benzyl-7,11-diazatricyclo[7.3.1]trideca-2,4-diene-6,12-dione
  • 1-[(1-benzyl-6-oxopiperidin-3-yl)methyl]-6-bromopyridin-2(1H)-one

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 6-Aminopyrimidin-2(1H)-one hydrochloride
  • cytosine
  • 6-aminobenz(cd)indol-2(1H)-one hydrochloride
  • 5-AMINOPYRIMIDIN-2(1H)-ONE
  • 4,6-Diaminopyrimidin-2(1H)-one hydrochloride
  • 1-Methyloctahydro-1,6-Naphthyridin-2(1H)-One Hydrochloride
  • N-((1-(3,4-difluorophenyl)-1H-tetrazol-5-yl)methyl)-2-(4-ethoxyphenoxy)acetamide
  • N-((1-(3,4-difluorophenyl)-1H-tetrazol-5-yl)methyl)-2-(p-tolyloxy)acetamide
  • N-((1-(3,4-difluorophenyl)-1H-tetrazol-5-yl)methyl)-2-(2-fluorophenoxy)acetamide
  • N-((1-(3,4-difluorophenyl)-1H-tetrazol-5-yl)methyl)-2-phenylacetamide
  • N-((1-(3,4-difluorophenyl)-1H-tetrazol-5-yl)methyl)-2-(4-fluorophenyl)acetamide
  • 2-([1,1'-biphenyl]-4-yl)-N-((1-(3,4-difluorophenyl)-1H-tetrazol-5-yl)methyl)acetamide
  • N-((1-(3,4-difluorophenyl)-1H-tetrazol-5-yl)methyl)-2-(thiophen-2-yl)acetamide
  • 3-(2-chlorophenyl)-N-((1-(3,4-difluorophenyl)-1H-tetrazol-5-yl)methyl)-5-methylisoxazole-4-carboxamide
  • N-((1-(3,4-difluorophenyl)-1H-tetrazol-5-yl)methyl)-2-(2-methyl-1H-indol-3-yl)-2-oxoacetamide
  • 1-(4-chlorophenyl)-N-((1-(3,4-difluorophenyl)-1H-tetrazol-5-yl)methyl)-5-oxopyrrolidine-3-carboxamide
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