6-AMINOPYRIMIDIN-2(1H)-ONE HYDROCHLORIDE

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Names

[ CAS No. ]:
6047-01-4

[ Name ]:
6-AMINOPYRIMIDIN-2(1H)-ONE HYDROCHLORIDE

[Synonym ]:
6-Aminopyrimidin-2(1H)-one hydrochloride
1,2,3,4,5,6-hexahydro-1,5-methano-pyrido[1,2-a][1,5]diazocin-8-one,monohydrochloride
(+/-)-cytisine hydrochloride
1,2,3,4,5,6-Hexahydro-1,5-methano-pyrido[1,2-a][1,5]diazocin-8-on,Monohydrochlorid

Chemical & Physical Properties

[ Boiling Point ]:
218ºC at 2 MM HG

[ Melting Point ]:
152-153ºC

[ Molecular Formula ]:
C4H6ClN3O

[ Molecular Weight ]:
147.56300

[ Exact Mass ]:
147.02000

[ PSA ]:
71.77000

[ LogP ]:
0.73530

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
HA4200000
CHEMICAL NAME :
Cytisine hydrochloride
CAS REGISTRY NUMBER :
6047-01-4
LAST UPDATED :
199109
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C11-H14-N2-O.Cl-H
MOLECULAR WEIGHT :
226.73
WISWESSER LINE NOTATION :
T C666 A GVN LM&TTJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
9400 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
REFERENCE :
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 35,161,1969
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1730 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - rigidity (including catalepsy)
REFERENCE :
BJPCBM British Journal of Pharmacology. (Macmillan Press Ltd., Houndmills, Basingstoke, Hants. RG21 2XS, UK) V.34- 1968- Volume(issue)/page/year: 35,161,1969

Safety Information

[ HS Code ]:
2933599090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (1R,9S)-N-benzyl cytisine
  • 11-benzyl-7,11-diazatricyclo[7.3.1]trideca-2,4-diene-6,12-dione
  • 1-[(1-benzyl-6-oxopiperidin-3-yl)methyl]-6-bromopyridin-2(1H)-one

DownStream

Customs

[ HS Code ]: 2933599090

[ Summary ]:
2933599090. other compounds containing a pyrimidine ring (whether or not hydrogenated) or piperazine ring in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Related Compounds

  • 6-Aminopyrimidin-2(1H)-one hydrochloride
  • cytosine
  • 6-aminobenz(cd)indol-2(1H)-one hydrochloride
  • 5-AMINOPYRIMIDIN-2(1H)-ONE
  • 4,6-Diaminopyrimidin-2(1H)-one hydrochloride
  • 1-Methyloctahydro-1,6-Naphthyridin-2(1H)-One Hydrochloride
  • rac-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl (2R,3S)-3-methyloxirane-2-carboxylate
  • rac-1-tert-butyl 3-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl) (2R,3R)-2-methylpiperidine-1,3-dicarboxylate
  • rac-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl (2R,3S)-4-ethyl-5-oxo-3-phenylmorpholine-2-carboxylate
  • rac-tert-butyl 4-[(1R,2S)-2-{[(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)oxy]carbonyl}cyclopropyl]piperidine-1-carboxylate
  • 2-{[(Tert-butoxy)carbonyl](3-cyanocyclobutyl)amino}acetic acid
  • rac-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl 2-[(1R,2S)-2-{[(tert-butoxy)carbonyl]amino}cyclopentyl]acetate
  • rac-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl (2R,5S)-5-({[(tert-butoxy)carbonyl]amino}methyl)oxolane-2-carboxylate
  • rac-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl (2R,3R)-2-(1,5-dimethyl-1H-pyrazol-4-yl)oxolane-3-carboxylate
  • rac-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl (2R,3R)-2-(1-methyl-1H-pyrazol-5-yl)oxolane-3-carboxylate
  • rac-1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl (1R,2R)-2-[4-(trifluoromethoxy)phenyl]cyclopropane-1-carboxylate
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