[3-chloro-4-(phenylmethoxy)phenyl]acetic acid

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Names

[ CAS No. ]:
60736-70-1

[ Name ]:
[3-chloro-4-(phenylmethoxy)phenyl]acetic acid

[Synonym ]:
VUFB9682
3-Chloro-4-benzyloxyphenylacetic acid
Benzofenac
EINECS 262-396-3
[3-chloro-4-(phenylmethoxy)phenyl]acetic acid
Acetic acid,(4-(benzyloxy)-3-chlorophenyl)
4-Benzyloxy-3-chlorophenylacetic acid
3-Chloro-4-(phenylmethoxy)benzeneacetic acid
3-chloro-4-benzylphenylacetic acid

Chemical & Physical Properties

[ Density]:
1.295g/cm3

[ Boiling Point ]:
442.8ºC at 760 mmHg

[ Molecular Formula ]:
C15H13ClO3

[ Molecular Weight ]:
276.71500

[ Flash Point ]:
221.6ºC

[ Exact Mass ]:
276.05500

[ PSA ]:
46.53000

[ LogP ]:
3.54610

[ Index of Refraction ]:
1.603

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
CY1576540
CHEMICAL NAME :
Benzeneacetic acid, 3-chloro-4-(phenylmethoxy)-
CAS REGISTRY NUMBER :
60736-70-1
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H13-Cl-O3
MOLECULAR WEIGHT :
276.73
WISWESSER LINE NOTATION :
QV1R CG DO1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2820 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,149,1982
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1960 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 7,149,1982

Safety Information

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • methyl 4-Benzyloxy-3-Chlorophenylacetate
  • 2-Chloroanisole
  • 3-CHLORO-4-METHOXYBENZYL CHLORIDE
  • 3-CHLORO-4-METHOXYBENZENEACETONITRILE
  • Methyl (3-chloro-4-hydroxyphenyl)acetate
  • Benzyl chloride

DownStream

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • [3-Chloro-4-(trifluoromethyl)phenyl]acetic acid
  • [3-Chloro-4-(methylsulfanyl)phenyl]acetic acid
  • 3-Chloro-4-isobutylphenylacetic acid
  • [3-Chloro-4-(2-methyl-4-oxo-4H-quinazolin-3-yl)-phenyl]-acetic acid ethyl ester; hydrochloride
  • (3-chloro-4-formylphenyl)acetic acid methyl ester
  • (3-chloro-4-hydrazinocarbonylphenyl)acetic acid methyl ester
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(4-((6-isopropoxy-2-methylpyrimidin-4-yl)amino)phenyl)propionamide
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide