1,1'-Pentamethylenebis[3-(2-chloroethyl)-3-nitrosourea]
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Names
[ CAS No. ]:
60784-44-3
[ Name ]:
1,1'-Pentamethylenebis[3-(2-chloroethyl)-3-nitrosourea]
Chemical & Physical Properties
[ Density]:
1.43g/cm3
[ Molecular Formula ]:
C11H20Cl2N6O4
[ Molecular Weight ]:
371.22000
[ Exact Mass ]:
370.09200
[ PSA ]:
130.52000
[ LogP ]:
2.42910
[ Index of Refraction ]:
1.581
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- YT9955000
- CHEMICAL NAME :
- Urea, 1,1'-pentamethylenebis(3-(2-chloroethyl)-3-nitroso-
- CAS REGISTRY NUMBER :
- 60784-44-3
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C11-H20-Cl2-N6-O4
- MOLECULAR WEIGHT :
- 371.27
- WISWESSER LINE NOTATION :
- ONN2GVM5MVNNO&2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 45 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema Liver - hepatitis (hepatocellular necrosis), diffuse Blood - changes in bone marrow (not otherwise specified)
- TYPE OF TEST :
- Sex chromosome loss and nondisjunction
MUTATION DATA
- TYPE OF TEST :
- Gene conversion and mitotic recombination
- TEST SYSTEM :
- Yeast - Saccharomyces cerevisiae
- DOSE/DURATION :
- 500 umol/L/16H
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 42,45,1977