Sinomenine HCl

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Names

[ CAS No. ]:
6080-33-7

[ Name ]:
Sinomenine HCl

[Synonym ]:
Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (9α,13α,14α)-, hydrochloride (1:1)
Cucoline, hydrochloride
(14α)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one hydrochloride (1:1)
(9α,13α,14α)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one hydrochloride (1:1)
Morphinan-6-one, 7,8-didehydro-4-hydroxy-3,7-dimethoxy-17-methyl-, (14α)-, hydrochloride (1:1)

Chemical & Physical Properties

[ Boiling Point ]:
513.6ºC at 760 mmHg

[ Melting Point ]:
231.0 to 235.0 °C

[ Molecular Formula ]:
C19H24ClNO4

[ Molecular Weight ]:
365.851

[ Flash Point ]:
264.4ºC

[ Exact Mass ]:
365.139374

[ PSA ]:
59.00000

[ LogP ]:
2.75800

[ Appearance of Characters ]:
white to beige

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
H2O: soluble20mg/mL, clear

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
QD2163000
CHEMICAL NAME :
9-alpha,13-alpha,14-alpha-Morphinan-6-one, 7,8-didehydro-3,7-dimethoxy-4-hydroxy-17-methyl-, hydrochloride
CAS REGISTRY NUMBER :
6080-33-7
LAST UPDATED :
198803
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C19-H23-N-O4.Cl-H
MOLECULAR WEIGHT :
365.89

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
4830 ug/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - cyanosis Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 52,157,1956

Safety Information

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
24/25

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
QD2163000

Related Compounds

  • sinomenine N-oxide
  • Sinomenine
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