Ethyl 2-Chloroacetoacetate

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Names

[ CAS No. ]:
609-15-4

[ Name ]:
Ethyl 2-Chloroacetoacetate

[Synonym ]:
Butanoic acid, 2-chloro-3-oxo-, ethyl ester
Butanoic acid, 4-chloro-3-oxo-, ethyl ester
Butanoic acid, 4-chloro-3-oxo-ethylester
MFCD00009141
Acetoacetic acid, 2-chloro-, ethyl ester (8CI)
ETHYL 2-CHLORO-3-OXO-BUTANOATE
Ethyl 4-chloro-3-oxobutanoate
EINECS 210-180-4
Ethyl 2-Chloroacetoacetate
Ethyl α-chloroacetoacetate
2-Chloroacetoacetic acid ethyl ester
Ethyl 4-chloroacetoacetate
Ethyl 2-chloro-3-oxobutanoate
ethyl2-chloro-3-oxobutanoate

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
225.5±0.0 °C at 760 mmHg

[ Melting Point ]:
-80 °C

[ Molecular Formula ]:
C6H9ClO3

[ Molecular Weight ]:
164.587

[ Flash Point ]:
50.0±0.0 °C

[ Exact Mass ]:
164.024017

[ PSA ]:
43.37000

[ LogP ]:
1.66

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.434

[ Storage condition ]:
2~8 ℃

[ Water Solubility ]:
17 g/L (20 ºC)

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H302-H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S16-S26-S36/37/39-S45-S61-S37/39

[ RIDADR ]:
UN 2920 8/PG 2

[ WGK Germany ]:
2

[ Packaging Group ]:
III

[ Hazard Class ]:
3.2

[ HS Code ]:
29183000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethyl acetoacetate
  • ethyl acetate
  • ethyl chloroacetate
  • Cyclopentane-1,2-dicarboximide
  • Diketene
  • Ethanol
  • acetic acid-(2,4,N-trichloro-anilide)
  • 2-chloro-3-oxobutanoic acid
  • 2-CHLORO-3-OXO-BUTYRONITRILE
  • (E)-ethyl 2-chloro-3-hydroxybut-2-enoate

DownStream

  • Ethyl 6-chloro-2-methylH-imidazo[1,2-a]pyridine-3-carboxylate
  • ethyl 4-methyl-2-phenyl-1,3-thiazole-5-carboxylate
  • 4-METHYL-2-PHENYL-1,3-THIAZOLE-5-CARBOXYLIC ACID
  • ETHYL2-(2-FLUORO-4-(TRIFLUOROMETHYL)PHENYL)-4-METHYLTHIAZOLE-5-CARBOXYLATE
  • Ethyl 4-methyl-2-(3-pyridinyl)-1,3-thiazole-5-carboxylate
  • 2-Methyl-3-ethoxycarbonylquinoxaline
  • Ethyl 6-chloro-2-methylimidazo[1,2-b]pyridazine-3-carboxylate
  • ETHYL 5-AMINO-4-CYANO-2-METHYL-3-FUROATE
  • diethyl 2-amino-5-methylfuran-3,4-dicarboxylate
  • ethyl 5-methyl-4-imidazolecarboxylate

Customs

[ HS Code ]: 2918300090

[ Summary ]:
2918300090 other carboxylic acids with aldehyde or ketone function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Fungal aerobic reductive dechlorination of ethyl 2-chloroacetoacetate by Saccharomyces cerevisiae: mechanism of a novel type of microbial dehalogenation.

ChemBioChem. 5(1) , 87-92, (2004)

Saccharomyces cerevisiae reduces the beta-keto ester ethyl 2-chloroacetoacetate to the respective chiral cis- and trans-beta-hydroxy esters. In the course of chiral reduction, competing dehalogenation...

Analysis of inhibitors of the site-specific recombination reaction mediated by Tn3 resolvase.

J. Mol. Biol. 206(2) , 295-304, (1989)

The Tn3-encoded resolvase protein promotes a site-specific recombination reaction between two directly repeated copies of the recombination site res. Several inhibitors that block this event in vitro ...

Synthesis and antiinflammatory activity of novel 2, 5-disubstituted thiophene derivatives. Badr SMI.

Turk. J. Chem. 35(1) , 131-143, (2011)


More Articles

Related Compounds

  • Ethyl 2-Chloroacetoacetate
  • ethyl 2-amino-2-prop-2-ynylpent-4-ynoate
  • ethyl 2-(3,4-dichlorophenyl)sulfanylacetate
  • ethyl 2-[(N-hexylanilino)methyl]benzoate
  • ethyl 2-cyanohept-6-enoate
  • ethyl 2-(pyrrolidin-1-ylamino)cyclopentene-1-carboxylate