N,N,2-Trimethylaniline

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Names

[ CAS No. ]:
609-72-3

[ Name ]:
N,N,2-Trimethylaniline

[Synonym ]:
MFCD00035789
2-(Dimethylamino)toluene
N,N,2-Trimethylaniline
N,N,2-Trimethylbenzenamine
EINECS 210-199-8
Benzenamine, N,N,2-trimethyl-

Chemical & Physical Properties

[ Density]:
0.9±0.1 g/cm3

[ Boiling Point ]:
185.9±9.0 °C at 760 mmHg

[ Melting Point ]:
-61.3ºC

[ Molecular Formula ]:
C9H13N

[ Molecular Weight ]:
135.206

[ Flash Point ]:
72.6±11.7 °C

[ Exact Mass ]:
135.104797

[ PSA ]:
3.24000

[ LogP ]:
2.79

[ Vapour Pressure ]:
0.7±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.544

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XU5800000
CHEMICAL NAME :
o-Toluidine, N,N-dimethyl-
CAS REGISTRY NUMBER :
609-72-3
BEILSTEIN REFERENCE NO. :
2205144
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C9-H13-N
MOLECULAR WEIGHT :
135.23
WISWESSER LINE NOTATION :
1N1&R B1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 90,260,1947
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
338 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
AISFAR Archivio Italiano di Scienze Farmacologiche. (Modena, Italy) V.1-11, 1932-42; Series 2: V.1-3, 1948-50; Series 3: V.1-15, 1951-65. Discontinued. Volume(issue)/page/year: 1,284,1951

Safety Information

[ Symbol ]:

GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H311-H331-H373-H412

[ Precautionary Statements ]:
P261-P273-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R23/24/25;R33;R52/53

[ Safety Phrases ]:
S23-S26-S36/37/39-S45-S61-S36/37-S28A

[ RIDADR ]:
UN 2810 6.1/PG 2

[ WGK Germany ]:
1

[ RTECS ]:
XU5800000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1(a)

[ HS Code ]:
2921430090

Synthetic Route

Precursor & DownStream

Precursor

  • Formaldehyde
  • o-Toluidine
  • 2-Me2N-α-Me3Si-benzylpotassium
  • 2-Chlorotoluene
  • Dimethylamine
  • 2-Bromotoluene
  • N,N-dimethyl O-(2,4,6-trimethylphenyl-sulfonyl) hydroxylamine
  • Methanol
  • Methylboronic acid

DownStream

  • leucoline
  • 8-Methylquinoline
  • 3-Chloroquinoline
  • o-Toluidine
  • Quinaldine
  • Benzenamine,N,2-dimethyl-
  • 3-Chloro-2-methylquinoline
  • 4-bromo-N,N,2-trimethylaniline
  • 1-Methylindole
  • o-xylene

Customs

[ HS Code ]: 2921430090

[ Summary ]:
HS:2921430090 toluidines and their derivatives; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Articles

Molecular Complexes and Their Spectra. X. Molecular Complexes between Iodine and N, N-Dimethylaniline Derivatives. Tsubomura H.

J. Am. Chem. Soc. 82(1) , 40-45, (1960)

Effect of tetramethylethylenediamine on the metalation of o- and p-N,N-dimethyltoluidines with n-butyllithium. Deuteration and electrophilic condensation of intermediate lithioamines. Ludt RE, et al.

J. Org. Chem. 35(5) , 1288-96, (1970)

Photo-dynamics of roseoflavin and riboflavin in aqueous and organic solvents. Zirak P, et al.

Chem. Phys. 358(1) , 111-122, (2009)


More Articles


Related Compounds

  • 4-bromo-N,N,2-trimethylaniline
  • 4-fluoro-N,N,2-trimethylaniline
  • 3-chloro-N,N,2-trimethylaniline
  • 4-Borono-N,N,2-trimethylaniline
  • 5-Methoxy-N,N,2-trimethylaniline
  • 4-[(E)-inden-1-ylidenemethyl]-N,N,2-trimethylaniline
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-((1-(dimethylcarbamoyl)piperidin-4-yl)methyl)-4-propyl-1,2,3-thiadiazole-5-carboxamide
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • (2,4-Difluorobenzyl)hydrazine dihydrochloride
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine