Piperidine hydrochloride

Names

[ Name ]:
Piperidine hydrochloride

[Synonym ]:
piperidine hydrochloride
EINECS 228-033-8
Piperidine, hydrochloride (1:1)
Piperidine hydrochloride (1:1)
Piperidinhydrochlorid
MFCD00012770

Chemical & Physical Properties

[ Density]:
1,12 g/cm3

[ Boiling Point ]:
106.4ºC at 760 mmHg

[ Melting Point ]:
245-248 °C(lit.)

[ Molecular Formula ]:
C₅H₁₂ClN

[ Molecular Weight ]:
121.608

[ Flash Point ]:
>230 °F

[ Exact Mass ]:
121.065826

[ PSA ]:
16.61000

[ Vapour density ]:
2.94 (vs air)

[ Vapour Pressure ]:
63.6 mm Hg ( 37.8 °C)

[ Water Solubility ]:
soluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TN0400000

CHEMICAL NAME :: Piperidine, hydrochloride

CAS REGISTRY NUMBER :: 6091-44-7

LAST UPDATED :: 199701

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C5-H11-N.Cl-H

MOLECULAR WEIGHT :: 121.63

WISWESSER LINE NOTATION :: T6NTJ &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 133 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,289,1972

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 330 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia Lungs, Thorax, or Respiration - cyanosis

REFERENCE :: JJPAAZ Japanese Journal of Pharmacology. (Japanese Pharmacological Soc., c/o Dept. of Pharmacology, Faculty of Medicine, Kyoto Univ., Sakyo-ku, Kyoto 606, Japan) V.1- 1951- Volume(issue)/page/year: 17,475,1967

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 657 mg/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Lungs, Thorax, or Respiration - cyanosis Nutritional and Gross Metabolic - body temperature decrease

REFERENCE :: AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 50,199,1903

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 112,36,1957

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 1 gm/kg

TOXIC EFFECTS :: Autonomic Nervous System - other (direct) parasympathomimetic Cardiac - pulse rate Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: AEXPBL Archiv fuer Experimentelle Pathologie und Pharmakologie. (Leipzig, Ger. Dem. Rep.) V.1-109, 1873-1925. For publisher information, see NSAPCC. Volume(issue)/page/year: 50,199,1903

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;

[ Risk Phrases ]:
R23/24/25;R36/37/38

[ Safety Phrases ]:
S36/37/39-S45-S28A-S26

[ RIDADR ]:
UN 2811 6.1/PG 3

[ WGK Germany ]:
1

[ RTECS ]:
TN0400000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
29333200

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-Benzylpiperidine
Glutaronitrile
2-Chloropyridine-N-oxide
Pyridine chlorhydrate
1-Allylpiperidine
Pyridine
2-chloro-1-piperidin-1-ylpropan-1-one
Piperidine
ethene

DownStream

1-Propanone,3-(1-piperidinyl)-1-(3,4,5-trimethoxyphenyl)-, hydrochloride (1:1)
Piperidine-1-sulfonyl chloride
1-piperidin-1-ylcyclohexane-1-carbonitrile
Piperidine-1-ylphosphonic aciddichloride
1-Piperidineacetonitrile,a-(4-methoxyphenyl)-
1-(4-fluorophenyl)-3-(1-piperidyl)propan-1-one hydrochloride
4-(2-piperidin-1-ylethyl)quinoline
1,2-diphenyl-3-(1-piperidyl)propan-1-one
1-benzoylpiperidine
1-Methylpiperidine

Customs

[ HS Code ]: 2933399090

[ Summary ]:
2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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