methopromazine

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Names

[ CAS No. ]:
61-01-8

[ Name ]:
methopromazine

[Synonym ]:
2-Methoxypromazine
Methopromazinum [INN-Latin]
Neoproma
[3-(2-methoxy-phenothiazin-10-yl)-propyl]-dimethyl-amine
RP 4632
Methoxypromazine
Tentone
2-Methoxy-10-(3'-dimethylaminopropyl)phenothiazine
Methopromazine
Tenton
Methopromazin
Metopromazina [INN-Spanish]
Levopromazine
[3-(2-Methoxy-phenothiazin-10-yl)-propyl]-dimethyl-amin

Chemical & Physical Properties

[ Density]:
1.143g/cm3

[ Boiling Point ]:
461.8ºC at 760 mmHg

[ Molecular Formula ]:
C18H22N2OS

[ Molecular Weight ]:
314.44500

[ Flash Point ]:
233.1ºC

[ Exact Mass ]:
314.14500

[ PSA ]:
41.01000

[ LogP ]:
4.31460

[ Index of Refraction ]:
1.603

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
SO7600000
CHEMICAL NAME :
Phenothiazine, 10-(3-(dimethylamino)propyl)-2-methoxy
CAS REGISTRY NUMBER :
61-01-8
LAST UPDATED :
198209
DATA ITEMS CITED :
5
MOLECULAR FORMULA :
C18-H22-N2-O-S
MOLECULAR WEIGHT :
314.48
WISWESSER LINE NOTATION :
T C666 BN ISJ B3N1&1 EO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
730 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
95 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
408 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
112 mg/kg
TOXIC EFFECTS :
Lungs, Thorax, or Respiration - respiratory depression
REFERENCE :
AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960 *** REVIEWS *** TOXICOLOGY REVIEW JMSCA9 Journal of Mental Science. (London, UK) V.4-108, 1857-1962. For publisher information, see BJPYAJ. Volume(issue)/page/year: 106,755,1960

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 2-Methoxyphenothiazine
  • 3-Chloro-N,N-dimethylpropan-1-amine
  • N'-[2-(2-bromo-phenylsulfanyl)-5-methoxy-phenyl]-N,N-dimethyl-propanediyldiamine
  • Methanol
  • Chlorpromazine hydrochloride

DownStream

Related Compounds

  • Methopromazine maleate
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • Butanoic acid, 2-nitro-, anhydride with hypofluorous acid (9CI)
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide