methopromazine

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Names

[ CAS No. ]:
61-01-8

[ Name ]:
methopromazine

[Synonym ]:
2-Methoxypromazine
Methopromazinum [INN-Latin]
Neoproma
[3-(2-methoxy-phenothiazin-10-yl)-propyl]-dimethyl-amine
RP 4632
Methoxypromazine
Tentone
2-Methoxy-10-(3'-dimethylaminopropyl)phenothiazine
Methopromazine
Tenton
Methopromazin
Metopromazina [INN-Spanish]
Levopromazine
[3-(2-Methoxy-phenothiazin-10-yl)-propyl]-dimethyl-amin

Chemical & Physical Properties

[ Density]:
1.143g/cm3

[ Boiling Point ]:
461.8ºC at 760 mmHg

[ Molecular Formula ]:
C₁₈H₂₂N₂OS

[ Molecular Weight ]:
314.44500

[ Flash Point ]:
233.1ºC

[ Exact Mass ]:
314.14500

[ PSA ]:
41.01000

[ LogP ]:
4.31460

[ Index of Refraction ]:
1.603

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SO7600000

CHEMICAL NAME :: Phenothiazine, 10-(3-(dimethylamino)propyl)-2-methoxy

CAS REGISTRY NUMBER :: 61-01-8

LAST UPDATED :: 198209

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C18-H22-N2-O-S

MOLECULAR WEIGHT :: 314.48

WISWESSER LINE NOTATION :: T C666 BN ISJ B3N1&1 EO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 730 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 95 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 408 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 112 mg/kg

TOXIC EFFECTS :: Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 125,101,1960 *** REVIEWS *** TOXICOLOGY REVIEW JMSCA9 Journal of Mental Science. (London, UK) V.4-108, 1857-1962. For publisher information, see BJPYAJ. Volume(issue)/page/year: 106,755,1960

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Methoxyphenothiazine
3-Chloro-N,N-dimethylpropan-1-amine
N'-[2-(2-bromo-phenylsulfanyl)-5-methoxy-phenyl]-N,N-dimethyl-propanediyldiamine
Methanol
Chlorpromazine hydrochloride

DownStream

Related Compounds

Methopromazine maleate
5-Fluoro-1-(2-(piperazin-1-yl)ethyl)-1H-benzo[d]imidazole
2-(5-amino-3-methyl-1H-pyrazol-1-yl)-3,6-dimethyl-3,4-dihydropyrimidin-4-one
2-[5-amino-4-(benzenesulfonyl)-3-[(3-fluorophenyl)amino]-1H-pyrazol-1-yl]-N-(3,4-difluorophenyl)acetamide
2-[(4-{4-[5-(Trifluoromethyl)pyridin-2-yl]piperazin-1-yl}piperidin-1-yl)methyl]quinolin-8-yl 2-methoxyacetate
8-[(4-{4-[3-Chloro-5-(trifluoromethyl)pyridin-2-yl]piperazin-1-yl}piperidin-1-yl)sulfonyl]quinoline
2-bromo-N-[(1-hydroxycyclohex-2-en-1-yl)methyl]benzamide
1-[(4-Chlorophenyl)methyl]-3-[(1-hydroxycyclohex-2-en-1-yl)methyl]urea
N-(4-carbamoylthiophen-3-yl)-5-nitrofuran-2-carboxamide
(2E)-N-[2-(furan-2-yl)-2-(thiophen-3-yl)ethyl]-3-(thiophen-2-yl)prop-2-enamide
N-[2-(furan-2-yl)-2-(thiophen-3-yl)ethyl]-1,3-benzothiazole-2-carboxamide

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