2,3-Dihydro-1-methylindol-2-one

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Names

[ CAS No. ]:
61-70-1

[ Name ]:
2,3-Dihydro-1-methylindol-2-one

[Synonym ]:
2,3-Dihydro-1-methylindol-2-one
N-Methylindol-2(3H)-one
2-INDOLINONE,1-METHYL
1-Methyl-2-oxindole
N-methyloxindole
N-Methyl-2-indolinone
MFCD00030253
EINECS 231-391-8
1-Methyloxindole
2H-Indol-2-one, 1,3-dihydro-1-methyl-
1-methylindolin-2-one
N-methyl-indol-2-one
1-Methyl-1,3-dihydro-2H-indol-2-one
1-Methyl-2-indolinone

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
346.0±31.0 °C at 760 mmHg

[ Melting Point ]:
85-88ºC(lit.)

[ Molecular Formula ]:
C₉H₉NO

[ Molecular Weight ]:
147.174

[ Flash Point ]:
172.3±16.0 °C

[ Exact Mass ]:
147.068420

[ PSA ]:
20.31000

[ LogP ]:
1.27

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.584

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NM2208800

CHEMICAL NAME :: 2-Indolinone, 1-methyl-

CAS REGISTRY NUMBER :: 61-70-1

BEILSTEIN REFERENCE NO. :: 0124173

LAST UPDATED :: 199709

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C9-H9-N-O

MOLECULAR WEIGHT :: 147.19

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1177 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: YKKZAJ Yakugaku Zasshi. Journal of Pharmacy. (Nippon Yakugakkai, 2-12-15 Shibuya, Shibuya-ku, Tokyo 150, Japan) No.1- 1881- Volume(issue)/page/year: 94,1620,1974

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26-36

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
NM2208800

[ HS Code ]:
2933790090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Oxindole
Dimethyl sulfate
2-Chloro-N-methyl-N-phenylacetamide
1-methylisatin
N-(2-chlorophenyl)-N-methylacetamide
2-[o-(N-Methylamino)phenyl]ethanol
methyl iodide
2-diazonio-1-(N-methylanilino)ethenolate
Pyrazole

DownStream

1-methylspiro[2H-indole-3,4'-piperidine]
1-Methylindole
1-Methylindoline
5-AMINO-1-METHYL-1,3-DIHYDRO-2H-INDOL-2-ONE
2-CHLORO-1-METHYL-1H-INDOLE-3-CARBALDEHYDE
1-methylisatin
5-BROMO-1-METHYL-2-OXOINDOLINE
2,2-dithiobis(1-methyl-N-phenyl-1H-indole-3-carboxamide)
1-methyl-5-sulfanyl-3H-indol-2-one
1-methyl-5-[(1-methyl-2-oxo-3H-indol-5-yl)disulfanyl]-3H-indol-2-one

Customs

[ HS Code ]: 2933790090

[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%

Articles

An Expedient Stereoselective Synthesis of Spirocyclopropyl Oxindoles from Indolin-2-One/N-Protected Indolin-2-Ones and Bromonitroalkenes. Roy S and Chen K.

J. Chin. Chem. Soc. 60(6) , 597-604, (2013)

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