L-leucine
Suppliers
Names
[ CAS No. ]:
61-90-5
[ Name ]:
L-leucine
[Synonym ]:
MFCD00002617
Glusate
H-L-GLU-OH
Leucine
L-GLU
(l)-leucine
EINECS 200-522-0
H-GLU-OH
[14C]-L-(+)-Leucine
GLU
[14C]-L-Glutamic acid
L-2-Amino-4-methylpentanoic acid
(2S)-α-Leucine
GLUTACID
4-Methyl-L-norvaline
LEUCINE, L-
l-Leu
Leucinum
[3H]-L-Glutamic acid
Leucine (USP)
L-Leucine
S-leucine
QVYZ1Y1&1 &&L or S Form
2-Amino-4-methylpentanoic acid, (S)-
H-Leu-OH
(S)-2-amino-4-methyl-pentanoic acid
L-(+)-glutamic acid
(S)-(+)-Leucine
Aciglut
(S)-leucine
glutamic
L-(-)-2-Amino-4-methylpentanoic acid
LEU
Glutaton
Chemical & Physical Properties
[ Density]:
1.0±0.1 g/cm3
[ Boiling Point ]:
225.8±23.0 °C at 760 mmHg
[ Melting Point ]:
286-288 ºC
[ Molecular Formula ]:
C6H13NO2
[ Molecular Weight ]:
131.173
[ Flash Point ]:
90.3±22.6 °C
[ Exact Mass ]:
131.094635
[ PSA ]:
63.32000
[ LogP ]:
0.73
[ Vapour Pressure ]:
0.0±0.9 mmHg at 25°C
[ Index of Refraction ]:
1.463
[ Water Solubility ]:
22.4 g/L (20 C)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- OH2850000
- CHEMICAL NAME :
- Leucine, L-
- CAS REGISTRY NUMBER :
- 61-90-5
- LAST UPDATED :
- 199706
- DATA ITEMS CITED :
- 13
- MOLECULAR FORMULA :
- C6-H13-N-O2
- MOLECULAR WEIGHT :
- 131.20
- WISWESSER LINE NOTATION :
- QVYZ1Y1&1 -L
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 5379 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - dyspnea Nutritional and Gross Metabolic - body temperature decrease
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2620 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- DOSE :
- 138 gm/kg
- SEX/DURATION :
- female 5-15 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - other measures of fertility Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 90 mg/kg
- SEX/DURATION :
- female 1-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Specific Developmental Abnormalities - other developmental abnormalities
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 90 mg/kg
- SEX/DURATION :
- female 1-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - body wall
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 90 mg/kg
- SEX/DURATION :
- female 1-6 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - craniofacial (including nose and tongue)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 60 mg/kg
- SEX/DURATION :
- female 6-9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - Central Nervous System Reproductive - Specific Developmental Abnormalities - eye/ear Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 60 mg/kg
- SEX/DURATION :
- female 6-9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Specific Developmental Abnormalities - urogenital system
MUTATION DATA
- TYPE OF TEST :
- Sister chromatid exchange
- TEST SYSTEM :
- Human Lymphocyte
- DOSE/DURATION :
- 10 mg/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 372,75,1996 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-RUSSIA:STEL 5 mg/m3 JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81818 No. of Facilities: 53 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 750 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81818 No. of Facilities: 1037 (estimated) No. of Industries: 4 No. of Occupations: 18 No. of Employees: 21979 (estimated) No. of Female Employees: 16153 (estimated)
Safety Information
[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
[ Hazard Codes ]:
Xi
[ Safety Phrases ]:
S24/25
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
OH2850000
[ HS Code ]:
29224995
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2922499990
[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%
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