N-Desmethylclozapine

Suppliers

Names

[ Name ]:
N-Desmethylclozapine

[Synonym ]:
3-chloro-6-piperazin-1-yl-5H-benzo[b][1,4]benzodiazepine
Normethylclozapine
BzATP triethylammonium salt
Desmethylclozapine
EINECS 200-659-6
Demethylclozapine
N-Demethylclozapine
MFCD00210189
N-desmethyl clozapine
Norclozapine

Chemical & Physical Properties

[ Density]:
1.38g/cm3

[ Boiling Point ]:
490.1ºC at 760 mmHg

[ Melting Point ]:
120-125°C

[ Molecular Formula ]:
C₁₇H₁₇ClN₄

[ Molecular Weight ]:
312.79700

[ Flash Point ]:
250.2ºC

[ Exact Mass ]:
312.11400

[ PSA ]:
39.66000

[ LogP ]:
3.22080

[ Index of Refraction ]:
1.709

[ Storage condition ]:
Store at RT

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS02, GHS06, GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H225-H301 + H311 + H331-H370

[ Precautionary Statements ]:
P210-P260-P280-P301 + P310-P311

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
20/22-36/37/38

[ Safety Phrases ]:
S22-S36-S45

[ RIDADR ]:
3249

[ WGK Germany ]:
3

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Piperazine
8-Chloro-11-oxo-10,11-dihydro-5H-dibenzo-1,4-diazepine
Clozapine
1-Bromo-4-chloro-2-nitrobenzene
Benzoicacid, 2-[(2-amino-4-chlorophenyl)amino]-
2-((4-CHLORO-2-NITROPHENYL)AMINO)BENZOIC ACID
Anthranilic acid

DownStream

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Development of a SPE-HPLC-MS/MS method for the determination of most prescribed pharmaceuticals and related metabolites in urban sewage samples.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 990 , 23-30, (2015)

Based on regional prescription data several pharmaceuticals with variable amounts of prescription and corresponding metabolites were selected and analyzed in influent and effluent samples of the sewag...

Predicting hERG activities of compounds from their 3D structures: development and evaluation of a global descriptors based QSAR model.

Eur. J. Med. Chem. 46 , 618-30, (2011)

A QSAR based predictive model of hERG activity in terms of 'global descriptors' has been developed and evaluated. The QSAR was developed by training 77 compounds covering a wide range of activities an...

Functional activation of G-proteins coupled with muscarinic acetylcholine receptors in rat brain membranes.

J. Pharmacol. Sci. 125(2) , 157-68, (2014)

The functional activation of Gi/o proteins coupled to muscarinic acetylcholine receptors (mAChRs) was investigated with the conventional guanosine-5'-O-(3-[(35)S]thio) triphosphate ([(35)S]GTPγS) bind...

N-Desmethylclozapine
N-Desmethylclozapine-d8
N-Desmethylclozapine-d8 hydrochloride
N-hydroxyquinoline-8-sulfonamide
N-octanoyl benzotriazole
N-[(acetylamino)carbonyl]-2-phenylbutanamide
N3-(Cyclopropylmethyl)-N1-ethyl-N3-methyl-1,3-butanediamine
Propanamide, 2-[[(4,5-dimethyl-2-oxazolyl)methyl]amino]-N,N-dimethyl-
2-(4-Methylcyclohexyl)propan-2-amine
2-(4-Ethylcyclohexyl)propan-2-amine
Benzenemethanamine, 5-fluoro-N-(1-methylhexyl)-2-nitro-
4-chloro-1-(4-methylcyclohexyl)-1H-pyrazol-3-amine
4-[3-Chloro-4-(1-hydroxyethyl)phenyl]-1-methylpiperazin-2-one
(5-(Methoxymethyl)isoxazol-3-yl)(2-methylpiperazin-1-yl)methanone
4-(Dimethylamino)oxan-3-ol
4-[(3-Bromophenyl)sulfonyl]-1-methyl-2-piperazinone

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