Sodium levothyroxine pentahydrate

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Names

[ Name ]:
Sodium levothyroxine pentahydrate

[Synonym ]:
MFCD00149110
EINECS 200-221-4
Sodium (2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate hydrate (1:1:5)
L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt, hydrate (1:1:5)
sodium,(2S)-2-amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3,5-diiodophenyl]propanoate,pentahydrate
L-Thyroxine (sodium salt pentahydrate)

Chemical & Physical Properties

[ Density]:
2.381

[ Melting Point ]:
207-210 (dec.)(lit.)

[ Molecular Formula ]:
C₁₅H₂₀I₄NNaO₉

[ Molecular Weight ]:
888.928

[ Exact Mass ]:
888.721436

[ PSA ]:
141.76000

[ LogP ]:
3.60140

[ Appearance of Characters ]:
powder

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
cell culture medium: 0.1 mg/mL

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YP2833760

CHEMICAL NAME :: L-Tyrosine, O-(4-hydroxy-3,5-diiodophenyl)-3,5-diiodo-, sodium salt, pentahydrate

CAS REGISTRY NUMBER :: 6106-07-6

LAST UPDATED :: 199504

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H10-I4-N-O4.Na.5H2-O

MOLECULAR WEIGHT :: 888.95

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Subcutaneous

DOSE :: 1 mg/kg

SEX/DURATION :: female 1-20 day(s) after conception

TOXIC EFFECTS :: Reproductive - Maternal Effects - other effects Reproductive - Effects on Embryo or Fetus - other effects to embryo

REFERENCE :: JOENAK Journal of Endocrinology. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1939- Volume(issue)/page/year: 139,275,1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X2466 No. of Facilities: 19 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 399 (estimated) No. of Female Employees: 308 (estimated)

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
40

[ Safety Phrases ]:
S22-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
YP2833760

Articles

Inducible, tightly regulated and growth condition-independent transcription factor in Saccharomyces cerevisiae.

Nucleic Acids Res. 42(17) , e130, (2014)

The precise control of gene expression is essential in basic biological research as well as in biotechnological applications. Most regulated systems available in yeast enable only the overexpression o...

Replisome-mediated translesion synthesis and leading strand template lesion skipping are competing bypass mechanisms.

J. Biol. Chem. 289(47) , 32811-23, (2014)

A number of different enzymatic pathways have evolved to ensure that DNA replication can proceed past template base damage. These pathways include lesion skipping by the replisome, replication fork re...

Mirolase, a novel subtilisin-like serine protease from the periodontopathogen Tannerella forsythia.

Biol. Chem. 396(3) , 261-75, (2015)

The genome of Tannerella forsythia, an etiological factor of chronic periodontitis, contains several genes encoding putative proteases. Here, we characterized a subtilisin-like serine protease of T. f...