6-Mercaptopurine monohydrate
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Names
[ CAS No. ]:
6112-76-1
[ Name ]:
6-Mercaptopurine monohydrate
[Synonym ]:
9H-purine-6-thiol, hydrate (1:1)
7H-purine-6-thiol, hydrate (1:1)
LEUKERIN MONOHYDRATE
6-Mercaptopurine monohydrate
6H-Purine-6-thione, 3,7-dihydro-, hydrate (1:1)
9H-Purine-6-thiol hydrate (1:1)
6MP H2O
MERCALEUKIN MONOHYDRATE
purin-6-thiol,monohydrate
1,7-Dihydro-6H-purine-6-thione hydrate (1:1)
6MP MONOHYDRATE
EINECS 212-968-3
MFCD03854445
7H-purine-6-thiol hydrate
6-Mercaptopurine hydrate
Chemical & Physical Properties
[ Boiling Point ]:
490.6ºC at 760 mmHg
[ Melting Point ]:
>300 °C(lit.)
[ Molecular Formula ]:
C5H6N4OS
[ Molecular Weight ]:
170.192
[ Flash Point ]:
250.5ºC
[ Exact Mass ]:
170.026230
[ PSA ]:
98.68000
[ LogP ]:
0.95120
[ Storage condition ]:
Store at 0-5
[ Stability ]:
Stable. Incompatible with strong oxidizing agents, acids, strong bases. Light sensitive.
[ Water Solubility ]:
INSOLUBLE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UP0400000
- CHEMICAL NAME :
- Purine-6-thiol, monohydrate
- CAS REGISTRY NUMBER :
- 6112-76-1
- LAST UPDATED :
- 199410
- DATA ITEMS CITED :
- 10
- MOLECULAR FORMULA :
- C5-H4-N4-S.H2-O
- MOLECULAR WEIGHT :
- 170.21
- WISWESSER LINE NOTATION :
- T56 BM DN FN HNJ ISH &QH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1250 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 224 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 27500 ug/kg
- SEX/DURATION :
- female 11 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - extra-embryonic structures (e.g., placenta, umbilical cord) Reproductive - Effects on Embryo or Fetus - fetotoxicity (except death, e.g., stunted fetus) Reproductive - Specific Developmental Abnormalities - musculoskeletal system
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 500 mg/kg
- SEX/DURATION :
- male 40 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 250 mg/kg
- SEX/DURATION :
- male 5 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - male fertility index (e.g. # males impregnating females per # males exposed to fertile nonpregnant females)
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 4 mg/kg
- SEX/DURATION :
- female 6-9 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Fertility - litter size (e.g. # fetuses per litter; measured before birth) Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants) Reproductive - Effects on Embryo or Fetus - fetal death
- TYPE OF TEST :
- Micronucleus test
- TYPE OF TEST :
- Micronucleus test
MUTATION DATA
- TEST SYSTEM :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg/40D (Intermittent)
- REFERENCE :
- DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 6,83,1983
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H302-H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xn:Harmful
[ Risk Phrases ]:
R22;R36/37/38
[ Safety Phrases ]:
S22-S36/37/39-S45
[ RIDADR ]:
NONH for all modes of transport
[ WGK Germany ]:
3
[ RTECS ]:
UP0400000
[ HS Code ]:
29335995
Customs
[ HS Code ]: 2933990090
[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%
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