5-Ethynyl-2'-deoxyuridine

Names

[ Name ]:
5-Ethynyl-2'-deoxyuridine

[Synonym ]:
5-ethynyl-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione
5-Ethynyl-2'-deoxyuridine

Chemical & Physical Properties

[ Density]:
1.55g/cm3

[ Melting Point ]:
199 °C

[ Molecular Formula ]:
C₁₁H₁₂N₂O₅

[ Molecular Weight ]:
252.22300

[ Exact Mass ]:
252.07500

[ PSA ]:
104.55000

[ Index of Refraction ]:
1.644

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7510000

CHEMICAL NAME :: Uridine, 2'-deoxy-5-ethynyl-

CAS REGISTRY NUMBER :: 61135-33-9

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C11-H12-N2-O5

MOLECULAR WEIGHT :: 252.25

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Sister chromatid exchange

TEST SYSTEM :: Human Lung

DOSE/DURATION :: 500 ug/L

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 117,317,1983

Safety Information

[ Symbol ]:

GHS08

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H340-H361

[ Precautionary Statements ]:
P201-P281-P308 + P313

[ Hazard Codes ]:
Xi

[ RIDADR ]:
NONH for all modes of transport

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

idoxuridine
5-Ethynyl-3',5'-di-O-p-toluyl-2'-deoxyuridine
1-[2-deoxy-3,5-di-O-(p-toluoyl)-β-D-erythro-pentofuranosyl]-5-iodouracil
3',5'-di-O-trifluoroacetyl-5-iodo-2'-deoxyuridine
TMS-acetylene
5-(1-chlorovinyl)-2'-deoxy-3',5'-di-O-(p-toluoyl)uridine
5-Hydroxy-2'-deoxyuridine
5-(Trifluoromethanesulfonyloxy)-2'-deoxyuridine

DownStream

Edoxudine
2-[[5-(5-ethenyl-2,4-dioxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]acetic acid
5-vinyl-2'-deoxyuridine
Uridine,5-acetyl-2'-deoxy- (9CI)
5-[2-(4-tert-butylphenyl)ethynyl]-1-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidine-2,4-dione

Articles

Oncogene-mediated regulation of p53 ISGylation and functions.

Oncotarget 5(14) , 5808-18, (2014)

Oncogene-mediated cellular transformation is a multistep process involving activation of growth-promoting pathways as well as inactivation of tumor suppressors. We recently found that ISGylation of th...

CD11c(hi) Dendritic Cells Regulate Ly-6C(hi) Monocyte Differentiation to Preserve Immune-privileged CNS in Lethal Neuroinflammation.

Sci. Rep. 5 , 17548, (2015)

Although the roles of dendritic cells (DCs) in adaptive defense have been defined well, the contribution of DCs to T cell-independent innate defense and subsequent neuroimmunopathology in immune-privi...

The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection.

PLoS Negl. Trop. Dis. 9 , e0003853, (2015)

Chromatin structure can control gene expression and can define specific transcription states. For example, bivalent methylation of histone H3K4 and H3K27 is linked to poised transcription in vertebrat...

5-ethynyl-2'-deoxyuridine
C-5-ethynyl-2'-deoxyuridine
5-ethynyl-2'-deoxyuridine-5'-triphosphate
5-Ethynyl-2'-deoxyuridine5'-triphosphatesodiumsalt
5'-O-(4,4'-dimethoxytrityl)-5-ethynyl-2'-deoxyuridine
5-Ethynyl-3',5'-di-O-p-toluyl-2'-deoxyuridine
4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
1-Benzyl-3-(iodomethyl)piperidin-4-ol
1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
(4-Methyl-tetrahydro-furan-2-yl)-methanol
N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
tert-Butyl-DL-alanine
4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide