o-Xylylene dichloride

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Names

[ CAS No. ]:
612-12-4

[ Name ]:
o-Xylylene dichloride

[Synonym ]:
1,2-Dichloroxylene
MFCD00000903
α,α′-dichloro-ortho-xylene
O-XYLYLENE CHLORIDE
EINECS 210-291-8
o-Xylylene dichloride
o-xylylenedichloride
Benzene, 1,2-bis(chloromethyl)-
1,2-Bis(chloromethyl)benzene
o-xylenedichloride
A,A'-DICHLORO-O-XYLENE
α,α'-Dichloro-o-xylene

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
239.5±0.0 °C at 760 mmHg

[ Melting Point ]:
51-55 °C(lit.)

[ Molecular Formula ]:
C8H8Cl2

[ Molecular Weight ]:
175.055

[ Flash Point ]:
107.8±0.0 °C

[ Exact Mass ]:
174.000305

[ LogP ]:
2.75

[ Vapour Pressure ]:
0.1±0.4 mmHg at 25°C

[ Index of Refraction ]:
1.545

[ Water Solubility ]:
hydrolysis

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ZE4085000
CHEMICAL NAME :
o-Xylene, alpha,alpha'-dichloro-
CAS REGISTRY NUMBER :
612-12-4
BEILSTEIN REFERENCE NO. :
2043675
LAST UPDATED :
199710
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C8-H8-Cl2
MOLECULAR WEIGHT :
175.06
WISWESSER LINE NOTATION :
G1R B1G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
2263 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Vascular - regional or general arteriolar or venous dilation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
1131 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Vascular - regional or general arteriolar or venous dilation
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
320 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
100 ug/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 191,79,1987

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314-H335

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
C:Corrosive;Xi:Irritant;

[ Risk Phrases ]:
R34;R36/37/38

[ Safety Phrases ]:
S26-S27-S28-S36/37/39-S45-S24/25-S61-S29-S28A

[ RIDADR ]:
UN 3261 8/PG 2

[ WGK Germany ]:
2

[ RTECS ]:
ZE4085000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
29036990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 1,2-Phenylenedimethanol
  • o-xylene
  • Formaldehyde
  • Benzyl chloride
  • Toluene
  • Dimethyl phthalate
  • Phthaloyl chloride
  • bis-(2-ethoxymethyl-benzyl)-amine
  • N-chlorosuccinimide
  • Hydrochloric acid

DownStream

  • 2-(chloromethyl)benzaldehyde
  • (2S)-2-amino-3-[2-(phosphonomethyl)phenyl]propanoic acid
  • Bicyclo[4.2.0]octa-1,3,5-trien-7-yl(methyl) ketone
  • Phthalane
  • 1,2-Phenylenedimethanol
  • [2-(chloromethyl)phenyl]methanol
  • Isoindoline
  • 2-Acetyl-1,2,3,4-tetrahydroisoquinoline-3-carboxylic Acid
  • 1,2-Phenylenedimethanamine
  • 3-Isochromanone

Customs

[ HS Code ]: 2903999090

[ Summary ]:
2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles

Solid-phase synthetic route to multiple derivatives of a fundamental peptide unit.

Molecules 15(7) , 4961-83, (2010)

Amino acids are Nature's combinatorial building blocks. When substituted on both the amino and carboxyl sides they become the basic scaffold present in all peptides and proteins. We report a solid-pha...

The synthesis and characterization of α-and β-1, 1-diiodo-3, 4-benzo-1-telluracyclopentane, C8 H8Tel2. Ziolo RF and Günther WHH.

J. Organomet. Chem. 146(3) , 245-251, (1978)


More Articles

Related Compounds

  • Grignard reagent of o-xylylene dichloride
  • o-Xylylene N,N-Diethylphosphoramidite
  • m-Xylylene dichloride
  • 2,2'-o-xylylene-di-benzoic acid
  • (η5-cyclopentadienyl)(η4-o-xylylene)cobalt
  • bis(μ-carbonyl)(μ-o-xylylene)bis[(η-cyclopentadienyl)cobalt]