4,4'-Bi-o-toluidine dihydrochloride

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Names

[ CAS No. ]:
612-82-8

[ Name ]:
4,4'-Bi-o-toluidine dihydrochloride

[Synonym ]:
(1,1'-Biphenyl)-4,4'-diamine, 3,3'-dimethyl-, dihydrochloride
O-TOLIDINE HYDROCHLORIDE
3,3'-Dimethyl-[1,1'-biphenyl]-4,4'-diamine dihydrochloride
8-Piperazin-1-yl-quinoline
MFCD00012960
3,3'-Dimethyl-4,4'-biphenyldiamine dihydrochloride
3,3'-Dimethyl-benzidin,Dihydrochlorid
o-Tolidine dihydroch
3,3'-Dimethylbiphenyl-4,4'-diamine dihydrochloride
Benzidine, 3,3'-dimethyl-, dihydrochloride
[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethyl-, dihydrochloride
3,3′-Dimethylbenzidine dihydrochloride
3,3'-dimethyl-benzidine,dihydrochloride
3,3'-dimethylbenzidine diammonium chloride
O-TolidineHydrochlorideGr
EINECS 210-322-5
o-Tolidine2HCl
THALLIUM ARSENATE
O-TOLIDINE DI HCL
4,4'-Bi-o-toluidine dihydrochloride
[1,1'-Biphenyl]-4,4'-diamine, 3,3'-dimethyl-, hydrochloride (1:2)
3,3'-Dimethylbenzidine dihydrochloride
4,4′-Diamino-3,3′-dimethylbiphenyl dihydrochloride
3,3'-Dimethyl-4,4'-diaminobiphenyl dihydrochloride
O-TOLIDINE DIHYDROCHLORIDE
ZR B1 DR DZ C1 &&2HCl

Chemical & Physical Properties

[ Boiling Point ]:
361ºC at 760 mmHg

[ Melting Point ]:
>300°C

[ Molecular Formula ]:
C14H18Cl2N2

[ Molecular Weight ]:
285.212

[ Exact Mass ]:
284.084717

[ PSA ]:
52.04000

[ LogP ]:
5.90120

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
DD1226000
CHEMICAL NAME :
Benzidine, 3,3'-dimethyl-, dihydrochloride
CAS REGISTRY NUMBER :
612-82-8
LAST UPDATED :
199709
DATA ITEMS CITED :
13
MOLECULAR FORMULA :
C14-H16-N2.2Cl-H
MOLECULAR WEIGHT :
285.24
WISWESSER LINE NOTATION :
ZR B1 DR DZ C1 &GH 2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1120 mg/kg/14D-C
TOXIC EFFECTS :
Endocrine - other changes Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
18200 mg/kg/13W-C
TOXIC EFFECTS :
Endocrine - changes in thymus weight Blood - changes in bone marrow (not otherwise specified) Blood - changes in erythrocyte (RBC) count
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1820 mg/kg/65W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Liver - tumors Skin and Appendages - tumors
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
15288 mg/kg/78W-C
TOXIC EFFECTS :
Tumorigenic - Carcinogenic by RTECS criteria Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
Specific locus test
TYPE OF TEST :
Sex chromosome loss and nondisjunction
TYPE OF TEST :
Sex chromosome loss and nondisjunction

MUTATION DATA

TYPE OF TEST :
Sister chromatid exchange
TEST SYSTEM :
Rodent - hamster Ovary
DOSE/DURATION :
20 mg/L
REFERENCE :
NTPTR* National Toxicology Program Technical Report Series. (Research Triangle Park, NC 27709) No.206- Volume(issue)/page/year: NTP-TR-390,1991 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1372 No. of Facilities: 132 (estimated) No. of Industries: 3 No. of Occupations: 6 No. of Employees: 1178 (estimated) No. of Female Employees: 105 (estimated)

Safety Information

[ Symbol ]:

GHS07, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H350-H411

[ Precautionary Statements ]:
P201-P273-P301 + P312 + P330-P308 + P313-P391-P501

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T:Toxic;N:Dangerousfortheenvironment;

[ Risk Phrases ]:
R22;R45;R51/53;R68

[ Safety Phrases ]:
S53-S45-S61

[ RIDADR ]:
UN 3077 9/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
DD1226000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Precursor & DownStream

Precursor

DownStream

  • 4,4'-Diisocyanato-3,3'-dimethylbiphenyl

Articles

Evidence that 4-aminobiphenyl, benzidine, and benzidine congeners produce genotoxicity through reactive oxygen species.

Environ. Mol. Mutagen. 48(5) , 404-13, (2007)

4-Aminobyphenyl (4-Ab), benzidine (Bz), and Bz congeners were evaluated for their ability to induce genotoxicity through an oxidative mechanism. The mutagenicity of these compounds was tested in the p...

ortho-Substituent effects on the in vitro and in vivo genotoxicity of benzidine derivatives.

Mutat. Res. 319(1) , 19-30, (1993)

Benzidine and its 3,3'-diamino, 3,3'-dimethyl, 3,3'-dimethoxy, 3,3'-difluoro, 3,3'-dichloro, 3,3'-dibromo, 3,3'-dicarbomethoxy and 3,3'-dinitro derivatives together with 2-nitrobenzidine and 3-nitrobe...

Iron(III) oxidized nucleophilic coupling of catechol with o-tolidine/p-toluidine followed by 1,10-phenanthroline as new and sensitivity improved spectrophotometric methods for iron present in chemicals, pharmaceutical, edible green leaves, nuts and lake water samples.

Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 86 , 152-8, (2012)

A nucleophile formed from iron(III) oxidized catechol in 0.1M hydrochloric acid couple with o-tolidine, system 1/p-toluidine, system 2 to produce dye product, λ max 520 nm. The system 1/2 obeys Beer's...


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Related Compounds

  • 4,4'-bi-o-toluidine sulphate
  • 4-(4-hydroxy-3-methylphenyl)-2-methylphenol
  • 4,4'-bi-m-toluidine dihydrogen bis(sulphate)
  • 4,4'-Bi-1,3-dioxolane,(R*,S*)- (9CI)
  • 4,4'-Methylene di-o-toluidine
  • 4,4'-(cyclohexane-1,3-diyl)di-o-toluidine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine