trans-1-(2-Chloroethyl)-3-(4-hydroxymethylcyclohexyl)-1-nitrosourea formate

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Names

[ CAS No. ]:
61367-11-1

[ Name ]:
trans-1-(2-Chloroethyl)-3-(4-hydroxymethylcyclohexyl)-1-nitrosourea formate

[Synonym ]:
trans-1-(2-Chloroethyl)-3-(4-hydroxymethylcyclohexyl)-1-nitrosourea formate
Urea,1-(2-chloroethyl)-3-(4-hydroxymethylcyclohexyl)-1-nitroso-,formate,(E)
(4-{[(2-chloroethyl)(nitroso)carbamoyl]amino}cyclohexyl)methyl formate

Chemical & Physical Properties

[ Density]:
1.39g/cm3

[ Molecular Formula ]:
C11H18ClN3O4

[ Molecular Weight ]:
291.73100

[ Exact Mass ]:
291.09900

[ PSA ]:
88.07000

[ LogP ]:
2.67680

[ Index of Refraction ]:
1.577

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YS4986300
CHEMICAL NAME :
Urea, 1-(2-chloroethyl)-3-(4-hydroxymethylcyclohexyl)-1-nit roso-, formate, (E)-
CAS REGISTRY NUMBER :
61367-11-1
LAST UPDATED :
199612
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C11-H18-Cl-N3-O4
MOLECULAR WEIGHT :
291.77
WISWESSER LINE NOTATION :
L6TJ AMVNNO&2G D1OVH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD10 - Lethal Dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
22 mg/kg
TOXIC EFFECTS :
Tumorigenic - active as anti-cancer agent
REFERENCE :
JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 23,1095,1980

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • trans-4-Aminocyclohexanemethanol
  • Formic Acid
  • 1-(2-chloroethyl)-3-[4-(hydroxymethyl)cyclohexyl]urea

DownStream

Related Compounds

  • N-({[2,3'-bifuran]-5-yl}methyl)-2-(2-methoxyphenoxy)acetamide
  • N-({[2,3'-bifuran]-5-yl}methyl)-2-(naphthalen-1-yl)acetamide
  • N-({[2,3'-bifuran]-5-yl}methyl)-2-(4-chlorophenoxy)acetamide
  • N-({[2,3'-bifuran]-5-yl}methyl)-2-phenyl-1,3-thiazole-4-carboxamide
  • N-({[2,3'-bifuran]-5-yl}methyl)-4-phenyloxane-4-carboxamide
  • N-({[2,3'-bifuran]-5-yl}methyl)-2,3-dihydro-1-benzofuran-5-sulfonamide
  • 5-bromo-N-{2-hydroxy-2-[5-(thiophen-3-yl)furan-2-yl]ethyl}pyridine-3-carboxamide
  • N-(2-{[2,2'-bithiophene]-5-yl}-2-hydroxyethyl)propanamide
  • N-(2-{[2,2'-bithiophene]-5-yl}-2-hydroxyethyl)cyclopropanecarboxamide
  • N-(2-{[2,2'-bithiophene]-5-yl}-2-hydroxyethyl)pent-4-enamide
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