Oxythiamine chloride hydrochloride

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Names

[ CAS No. ]:
614-05-1

[ Name ]:
Oxythiamine chloride hydrochloride

[Synonym ]:
Thiazolium,3-((1,4-dihydro-2-methyl-4-oxo-5-pyrimidinyl)methyl)-5-(2-hydroxyethyl)-4-methyl-,chloride,monohydrochloride
5-(2-Hydroxy-aethyl)-4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thiazolium,Chlorid-hydrochlorid
OXYTHIAMINE CHLORIDE HCL
5-(2-hydroxy-ethyl)-4-methyl-3-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thiazolium,chloride-hydrochloride
5-(2-Hydroxyethyl)-3-(4-hydroxy-2-methyl-5-pyrimidinylmethyl)-4-methylthiazolium chloride
5-[[5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium-3-yl]methyl]-2-methyl-1H-pyrimidin-6-one,chloride,hydrochloride
thiazolium,5-(2-hydroxyethyl)-3-[(4-hydroxy-2-methyl-5-pyrimidinyl)methyl]-4-methyl-,chloride,hydrochloride(1:1:1)
MFCD00050656

Chemical & Physical Properties

[ Molecular Formula ]:
C12H16Cl2N4O2S

[ Molecular Weight ]:
351.25200

[ Exact Mass ]:
350.03700

[ PSA ]:
107.56000

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
XJ7034100
CHEMICAL NAME :
Thiazolium, 3-((1,4-dihydro-2-methyl-4-oxo-5-pyrimidinyl)methyl)- 5-(2-hydroxyethyl)-4- methyl-, chloride, monohydrochloride
CAS REGISTRY NUMBER :
614-05-1
LAST UPDATED :
199707
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H16-N3-O2-S.Cl.Cl-H

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Mammal - species unspecified
DOSE/DURATION :
1835 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
VMDKAM Voprosy Meditsinskoi Khimii. Problems of Medical Chemistry. (V/O Me zhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1955- Volume(issue)/page/year: 33,70,1987

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ RTECS ]:
XJ7034100

[ HS Code ]:
2934100090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Thiamine
  • 4(1H)-Pyrimidinone, 5-(aminomethyl)-2-methyl- (9CI)
  • 5-(Hydroxymethyl)-2-methylpyrimidin-4(1H)-one
  • 5-Pyrimidineaceticacid, 3,4-dihydro-2-methyl-4-oxo-, ethyl ester
  • Sulfurol
  • 5-bromomethyl-2-methyl-3H-pyrimidin-4-one
  • N-(2-methyl-6-oxo-1,6-dihydro-pyrimidin-5-ylmethyl)-thioformamide
  • 2-chloro-3-oxopentyl acetate

DownStream

  • oxythiamine disulfide
  • Hydrochloric acid

Customs

[ HS Code ]: 2934100090

[ Summary ]:
2934100090 other compounds containing an unfused thiazole ring (whether or not hydrogenated) in the structure VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0%

Articles

Inhibition of protein phosphorylation in MIA pancreatic cancer cells: confluence of metabolic and signaling pathways.

J. Proteome Res. 9 , 980-989, (2010)

Oxythiamine (OT), a transketolase inhibitor, is known to inhibit pancreatic cancer cell proliferation. In this study, we investigated the effect of inhibition of the transketolase pathway on signaling...

The in vitro and in vivo anti-metastatic efficacy of oxythiamine and the possible mechanisms of action.

Clin. Exp. Metastasis 27 , 341-349, (2010)

This study examined the anti-metastatic effects of oxythiamine (OT) both in cell culture and in vivo. Cell culture results revealed that OT (0-20 microM) significantly inhibited the invasion and migra...


More Articles

Related Compounds

  • Datelliptium chloride hydrochloride
  • nicotinoyl chloride, hydrochloride
  • TETRAPHENYLARSONIUM CHLORIDE HYDROCHLORIDE
  • dimethylaminoacetyl chloride hydrochloride
  • Nicotinoyl chloride hydrochloride
  • ISONICOTINOYL CHLORIDE HYDROCHLORIDE