(E)-Chalcone

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Names

[ CAS No. ]:
614-47-1

[ Name ]:
(E)-Chalcone

[Synonym ]:
Phenyl (E)-2-phenylethenyl ketone
RV1U1R &&E Form
Phenyl styryl ketone
2-Propen-1-one, 1,3-diphenyl-, (E)-
a-Benzylideneacetophenone
b-Phenylacrylophenone
β-Phenylacrylophenone
1-Benzoyl-2-phenylethylene
chalcone
trans-benzylideneacetophenone
EINECS 202-330-2
(2E)-1,3-diphenylprop-2-en-1-one
(E)-benzylideneacetophenone
phenyl trans-styryl ketone
trans-benzalacetophenone
(E)-1-Benzoyl-2-phenylethylene
2-Propen-1-one, 1,3-diphenyl-, (2E)-
trans-Chalcone
MFCD00003082
(2E)-1,3-Diphenyl-2-propen-1-one
β-Benzoylstyrene
b-Benzoylstyrene

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
346.6±25.0 °C at 760 mmHg

[ Melting Point ]:
55-57ºC

[ Molecular Formula ]:
C₁₅H₁₂O

[ Molecular Weight ]:
208.255

[ Flash Point ]:
150.1±18.1 °C

[ Exact Mass ]:
208.088821

[ PSA ]:
17.07000

[ LogP ]:
4.01

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.625

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37

[ Safety Phrases ]:
S22-S36/37/39-S45

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
UD5576750

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

1-Propanone, 2,3-dibromo-1,3-diphenyl-
Ciprofloxacin Hydrochloride
Phenylboronic acid
trans-1,3-Diphenyl-2-propen-1-ol
Benzoyl chloride
Benzaldehyde
2-Bromoacetophenone
styrylboronic acid
Acetophenone

DownStream

2H-1-Benzopyran-2-one,4-hydroxy-3-(3-oxo-1,3-diphenylpropyl)-
N'-Acetylacetohydrazide
1-(3,5-diphenyl-3,4-dihydropyrazol-2-yl)ethanone
Ethyl benzoate
Benzaldehyde
benzoic acid
2-Phenylacetophenone
6-methyl-2,4-diphenyl-7,8-dihydro-5H-1,6-naphthyridine
1,5-diphenylpentan-3-ylbenzene
2,4,6-TRIPHENYLPYRYLIUM TETRAFLUOROBORATE

Articles

Impact of induced fit on ligand binding to the androgen receptor: a multidimensional QSAR study to predict endocrine-disrupting effects of environmental chemicals.

J. Med. Chem. 48 , 5666-74, (2005)

We investigated the influence of induced fit of the androgen receptor binding pocket on free energies of ligand binding. On the basis of a novel alignment procedure using flexible docking, molecular d...

A chemical screening approach reveals that indole fluorescence is quenched by pre-fibrillar but not fibrillar amyloid-beta.

Bioorg. Med. Chem. Lett. 19 , 4952-7, (2009)

Aggregated amyloid-beta (Abeta) peptide is implicated in the pathology of Alzheimer's disease. In vitro and in vivo, these aggregates are found in a variety of morphologies, including globular oligome...

Novel chalcone derivatives as potent Nrf2 activators in mice and human lung epithelial cells.

J. Med. Chem. 54 , 4147-59, (2011)

Nrf2-mediated activation of antioxidant response element is a central part of molecular mechanisms governing the protective function of phase II detoxification and antioxidant enzymes against carcinog...