2-Hydroxycinnamic acid

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Names

[ CAS No. ]:
614-60-8

[ Name ]:
2-Hydroxycinnamic acid

[Synonym ]:
(2E)-3-(2-Hydroxyphenyl)-2-propenoic acid
(2E)-3-(2-Hydroxyphenyl)acrylic acid
(E)-o-coumaric acid
trans-2-coumaric acid
o-Coumaric acid
(E)-3-(2-Hydroxyphenyl)-2-propenoic acid
Cinnamic acid, o-hydroxy-, (E)-
Coumaric acid
2-Propenoic acid, 3-(2-hydroxyphenyl)-, (E)-
o-Hydroxy-trans-cinnamic acid
2-Hydroxycinnamic acid, (E)-
QV1U1R BQ &&E or trans Form
(E)-3-(2-Hydroxyphenyl)acrylic acid
Cinnamic acid, o-hydroxy-
2-Propenoic acid, 3-(2-hydroxyphenyl)-, (2E)-
(2E)-3-(2-Hydroxyphenyl)prop-2-enoic acid
EINECS 210-386-4
trans-2-Hydroxycinnamic acid
trans-o-Coumaric Acid
trans-o-Hydroxycinnamic acid
o-Hydroxycinnamic acid
2-Hydroxycinnamic acid
(E)-2-Hydroxycinnamic acid
(E)-o-Hydroxycinnamic acid
(E)-3-(2-Hydroxyphenyl)prop-2-enoic acid
MFCD00004379
ortho-Hydroxycinnamic acid

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
348.0±17.0 °C at 760 mmHg

[ Melting Point ]:
217ºC

[ Molecular Formula ]:
C9H8O3

[ Molecular Weight ]:
164.158

[ Flash Point ]:
178.5±17.4 °C

[ Exact Mass ]:
164.047348

[ PSA ]:
57.53000

[ LogP ]:
2.43

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.660

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
GD9090000
CHEMICAL NAME :
Cinnamic acid, o-hydroxy-, (E)-
CAS REGISTRY NUMBER :
614-60-8
BEILSTEIN REFERENCE NO. :
1100900
LAST UPDATED :
199701
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C9-H8-O3
MOLECULAR WEIGHT :
164.17
WISWESSER LINE NOTATION :
QV1U1R BQ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
180 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#02587

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301-H315-H319-H335

[ Precautionary Statements ]:
P261-P301 + P310-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;Xn:Harmful;

[ Risk Phrases ]:
R22;R36/37/38

[ Safety Phrases ]:
S26-S24/25-S36

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

[ RTECS ]:
GD9090000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • (E)-3-(2-Hydroxy-phenyl)-acrylic acid ethyl ester
  • Coumarin
  • Malonic acid
  • 2-Methylbenzyl Alcohol
  • β-D-(1-O-acetyl-3,6-O-p-E-dicoumaroyl)-fructofuranosyl-α-D-(4'-O-acetyl-2'-O-p-E-coumaroyl)-glucopyranoside
  • 3-methyl-4-nitro-5-[2-(2-hydroxyphenyl)ethenyl]isoxazole
  • iodophenol
  • Acrylic acid
  • 4-Chloro-2-nitrophenyl 2'-hydroxycinnamate

DownStream

  • Benzofuran-2-carboxylic acid
  • 3-(2-Hydroxyphenyl)propionate
  • Coumarin
  • 2H-1-Benzopyran-2-one,3,4-dihydro-6-hydroxy-
  • 3-Amino-3-(2-hydroxyphenyl)propionic acid
  • 3-(2,5-Dimethoxyphenyl)acrylic acid
  • 2-Methoxycinnamic acid
  • 2-ACETOXYCINNAMIC ACID
  • Carbon dioxide

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Related Compounds

  • 2-HYDROXYCINNAMIC ACID
  • 2-hydroxycinnamic acid
  • 5-BROMO-2-HYDROXYCINNAMIC ACID
  • 3-nitro-2-hydroxycinnamic acid
  • 5-Fluoro-2-hydroxycinnamic acid
  • 2-hydroxycinnamic acid methyl ester
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-(4-Bromophenyl)-5-methyl-1H-1,2,4-triazole
  • 1-(3-Amino-3-phenylpyrrolidin-1-yl)-2,2,2-trifluoroethan-1-one
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • (2S,4S)-2-[(azetidin-1-yl)methyl]-4-methoxypyrrolidine
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • benzyl N-{3-cyano-1-[(furan-2-yl)methyl]-4,5-dimethyl-1H-pyrrol-2-yl}carbamate
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide