rolipram
Suppliers
Names
[ CAS No. ]:
61413-54-5
[ Name ]:
rolipram
[Synonym ]:
4-[3-(Cyclopentyloxy)-4-methoxyphenyl]pyrrolidin-2-one
(R,S)-Rolipram
4-(3-cyclopentyloxy-4-methoxy-phenyl)-pyrrolidin-2-one
(±)-Rolipram
Adeo
[3H]-Rolipram
Rolipram
2-Pyrrolidinone, 4-[3-(cyclopentyloxy)-4-methoxyphenyl]-
4-(3-cyclopentyloxy-4-methoxyphenyl)pyrrolidin-2-one
4-[3-(Cyclopentyloxy)-4-methoxyphenyl]-2-pyrrolidinone
EINECS 262-771-1
Rolipramum [Latin]
T5MVTJ DR DO1 CO- AL6TJ
MFCD00270906
Chemical & Physical Properties
[ Density]:
1.2±0.1 g/cm3
[ Boiling Point ]:
472.7±45.0 °C at 760 mmHg
[ Melting Point ]:
127-133ºC
[ Molecular Formula ]:
C16H21NO3
[ Molecular Weight ]:
275.343
[ Flash Point ]:
239.7±28.7 °C
[ Exact Mass ]:
275.152130
[ PSA ]:
47.56000
[ LogP ]:
1.43
[ Vapour Pressure ]:
0.0±1.2 mmHg at 25°C
[ Index of Refraction ]:
1.552
[ Storage condition ]:
0-6°C
[ Water Solubility ]:
H2O: 0.2 mg/mL
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UY5749237
- CHEMICAL NAME :
- 2-Pyrrolidinone, 4-(3-(cyclopentyloxy)-4-methoxyphenyl)-
- CAS REGISTRY NUMBER :
- 61413-54-5
- LAST UPDATED :
- 199806
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C16-H21-N-O3
- MOLECULAR WEIGHT :
- 275.38
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BPBLEO Biological and Pharmaceutical Bulletin. (Pharmaceutical Society of Japan, 2-12-15-201 Shibuya Shibuya-ku, Tokyo 150, Japan) V.16- 1993- Volume(issue)/page/year: 17,498,1994 ** OTHER MULTIPLE DOSE TOXICITY DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1400 mg/kg/14D-I
- TOXIC EFFECTS :
- Cardiac - other changes Gastrointestinal - changes in structure or function of salivary glands Liver - hepatitis (hepatocellular necrosis), zonal
- REFERENCE :
- PHTOEH Pharmacology and Toxicology (Copenhagen). (Munksgaard International Pub., POB 2148, DK-1016 Copenhagen K, Denmark) V.60- 1987- Volume(issue)/page/year: 78,44,1996
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 364 mg/kg/26W-I
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - urine volume increased Blood - pigmented or nucleated red blood cells Nutritional and Gross Metabolic - weight loss or decreased weight gain
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 31,1465,1997
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 910 mg/kg/26W-I
- TOXIC EFFECTS :
- Gastrointestinal - changes in structure or function of salivary glands Gastrointestinal - nausea or vomiting
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 31,1527,1997
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Primate - monkey
- DOSE/DURATION :
- 448 mg/kg/4W-I
- TOXIC EFFECTS :
- Behavioral - coma Gastrointestinal - nausea or vomiting Related to Chronic Data - death
- REFERENCE :
- KSRNAM Kiso to Rinsho. Clinical Report. (Yubunsha Co., Ltd., 1-5, Kanda Suda-Cho, Chiyoda-ku, KS Bldg., Tokyo 101, Japan) V.1- 1960- Volume(issue)/page/year: 31,1491,1997
Safety Information
[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves
[ Hazard Codes ]:
Xi
[ Risk Phrases ]:
R36/37/38
[ Safety Phrases ]:
26-36
[ RIDADR ]:
UN 3249
[ WGK Germany ]:
3
[ RTECS ]:
UY5749237
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1(b)
[ HS Code ]:
2933790090
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2933790090
[ Summary ]:
2933790090. other lactams. VAT:17.0%. Tax rebate rate:9.0%. . MFN tariff:9.0%. General tariff:20.0%
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