5-Nitroindole

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Names

[ CAS No. ]:
6146-52-7

[ Name ]:
5-Nitroindole

[Synonym ]:
MFCD00005673
5-nitro-indol
5-nitro-indole
5-Nitroindolyl radical
1H-Indole, 5-nitro-
5-nitrolindole
5-Nitroindole
5-NO2-indole
EINECS 228-153-0
Nitroindole
5-Nitro-1H-indole

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
362.6±15.0 °C at 760 mmHg

[ Melting Point ]:
140-142 °C(lit.)

[ Molecular Formula ]:
C8H6N2O2

[ Molecular Weight ]:
162.15

[ Flash Point ]:
173.1±20.4 °C

[ Exact Mass ]:
162.042923

[ PSA ]:
61.61000

[ LogP ]:
2.53

[ Vapour Pressure ]:
0.0±0.8 mmHg at 25°C

[ Index of Refraction ]:
1.723

[ Storage condition ]:
-20°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NM1168200
CHEMICAL NAME :
Indole, 5-nitro-
CAS REGISTRY NUMBER :
6146-52-7
LAST UPDATED :
199410
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H6-N2-O2
MOLECULAR WEIGHT :
162.16
WISWESSER LINE NOTATION :
T56 BMJ INW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :
Mutation in microorganisms
TEST SYSTEM :
Bacteria - Salmonella typhimurium
DOSE/DURATION :
50 nmol/plate
REFERENCE :
MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,169,1986

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H318

[ Precautionary Statements ]:
P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xn:Harmful

[ Risk Phrases ]:
R22

[ Safety Phrases ]:
S26-S39-S45-S36/37

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
NM1168200

[ HS Code ]:
2933990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 5-Nitro-1H-indole-3-carbaldehyde
  • 5-Chloroindole
  • 2-Ethynyl-4-nitroaniline
  • tert-Butyl 5-nitro-1H-indole-1-carboxylate
  • 5-Nitroindoline
  • 1-(4-methylphenyl)sulfonyl-5-nitroindole
  • 4-nitro-2-[(trimethylsilyl)ethynyl]aniline
  • 2-Iodo-4-nitroaniline
  • 5-Bromoindole
  • 3-Vinyl-2-pyrrolidinone

DownStream

  • 3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitro-1H-indole
  • 1-(4-fluorophenyl)-3-(1-methyl-3,6-dihydro-2H-pyridin-4-yl)-5-nitroindole
  • 4-(5-Amino-1-methyl-1H-indol-3-ylmethyl)-3-methoxy-benzoic acid methyl ester
  • 5-Nitroindoline
  • 5-Nitrogramine
  • 1-Methyl-5-Nitroindole
  • 1-METHYL-4-NITRO-1H-INDOLE
  • 1-ethyl-5-nitroindole
  • (5-Nitro-1h-indol-1-yl)acetic acid
  • 1H-Indol-5-amine,1-ethyl-(9CI)

Customs

[ HS Code ]: 2933990090

[ Summary ]:
2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles

Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution.

Nat. Biotechnol. 22(6) , 755-9, (2004)

DNA polymerases recognize their substrates with exceptionally high specificity, restricting the use of unnatural nucleotides and the applications they enable. We describe a strategy to expand the subs...

Hybridization properties of long nucleic acid probes for detection of variable target sequences, and development of a hybridization prediction algorithm.

Nucleic Acids Res. 38(21) , e195, (2010)

One of the main problems in nucleic acid-based techniques for detection of infectious agents, such as influenza viruses, is that of nucleic acid sequence variation. DNA probes, 70-nt long, some includ...

Use of 5-nitroindole-2'-deoxyribose-5'-triphosphate for labelling and detection of oligonucleotides.

Nucleosides Nucleotides 17(1-3) , 555-64, (1998)

The 5'-triphosphate of 5-nitroindole-2'-deoxyriboside has been shown to be a good substrate for terminal deoxynucleotidyl transferase (TdT). An antibody has been prepared for the detection of 5-nitroi...


More Articles

Related Compounds

  • N-Boc-5-nitroindole
  • 3-iodo-5-nitroindole
  • 6-Iodo-5-nitroindole
  • N-tosyl-5-nitroindole
  • N-tosyl-5-nitroindole
  • 3-Bromo-5-nitroindole
  • N-[1-(3-Bromobenzyl)piperidin-3-yl]-1H-indazol-5-amine
  • 3-[[3-[(1H-Indazol-5-yl)amino]piperidin-1-yl]methyl]phenol
  • N-[1-(3-Ethynylbenzyl)piperidin-3-yl]-1H-indazol-5-amine
  • N5-(1-Benzylpiperidin-3-yl)-1H-indazole-3,5-diamine
  • N-[1-[(Benzofuran-5-yl)methyl]piperidin-3-yl]-1H-indazol-5-amine
  • 5-[[3-[(1H-Indazol-5-yl)amino]piperidin-1-yl]methyl]-2-methylphenol
  • N-[1-(3,4-Dichlorobenzyl)pyrrolidin-3-yl]-1H-indazol-5-amine
  • N-[1-(3-Ethoxybenzyl)piperidin-3-yl]-1H-indazol-5-amine
  • N-[1-(3-Methylbenzyl)piperidin-3-yl]-1H-indazol-5-amine
  • N-[1-(2-Methoxybenzyl)piperidin-3-yl]-1H-indazol-5-amine
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