4-Methoxy-1,3-benzenediamine

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Names

[ CAS No. ]:
615-05-4

[ Name ]:
4-Methoxy-1,3-benzenediamine

[Synonym ]:
4-Methoxybenzene-1,3-diamine
EINECS 210-406-1
MFCD00007803
1,3-Benzenediamine, 4-methoxy-
4-Methoxy-1,3-benzenediamine
Esomeprazole Impurity 34

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
305.9±22.0 °C at 760 mmHg

[ Melting Point ]:
66-68ºC

[ Molecular Formula ]:
C7H10N2O

[ Molecular Weight ]:
138.167

[ Flash Point ]:
164.6±16.0 °C

[ Exact Mass ]:
138.079315

[ PSA ]:
61.27000

[ LogP ]:
-0.26

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.619

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
BZ8580500
CHEMICAL NAME :
Anisole, 2,4-diamino-
CAS REGISTRY NUMBER :
615-05-4
BEILSTEIN REFERENCE NO. :
2085522
LAST UPDATED :
199710
DATA ITEMS CITED :
26
MOLECULAR FORMULA :
C7-H10-N2-O
MOLECULAR WEIGHT :
138.19
WISWESSER LINE NOTATION :
ZR CZ DO1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rabbit
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
460 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - ataxia Skin and Appendages - hair
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
116 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - urine volume increased Kidney, Ureter, Bladder - other changes in urine composition
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
65100 ug/kg
SEX/DURATION :
female 10 day(s) after conception
TOXIC EFFECTS :
Reproductive - Fertility - pre-implantation mortality (e.g. reduction in number of implants per female; total number of implants per corpora lutea)
TYPE OF TEST :
DNA damage
TYPE OF TEST :
Sister chromatid exchange

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - mouse Lymphocyte
REFERENCE :
JEPTDQ Journal of Environmental Pathology and Toxicology. (Park Forest South, IL) V.1-5(3), 1977-81(?). For publisher information, see JEPOEC. Volume(issue)/page/year: 1(1),87,1977 *** REVIEWS *** IARC Cancer Review:Animal Sufficient Evidence IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,103,1982 IARC Cancer Review:Human No Adequate Data IMEMDT IARC Monographs on the Evaluation of Carcinogenic Risk of Chemicals to Man. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) V.1- 1972- Volume(issue)/page/year: 27,103,1982 IARC Cancer Review:Group 2B IMSUDL IARC Monographs, Supplement. (WHO Publications Centre USA, 49 Sheridan Ave., Albany, NY 12210) No.1- 1979- Volume(issue)/page/year: 7,56,1987 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-FINLAND;Carcinogen JAN 1993 OEL-GERMANY;Carcinogen JAN 1993 OEL-SWEDEN;Carcinogen JAN 1993 OEL-SWITZERLAND;Carcinogen JAN 1993 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO 2,4-DIAMINOANISOLE-air:CA lowest feasible conc. REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992

Safety Information

[ Symbol ]:

GHS07, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H302-H341-H350-H411

[ Precautionary Statements ]:
P201-P273-P281-P308 + P313

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T: Toxic;N: Dangerous for the environment;

[ Risk Phrases ]:
R45;R22;R51/53;R68

[ Safety Phrases ]:
53-45-61

[ RIDADR ]:
UN 3077

[ RTECS ]:
BZ8580500

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

[ HS Code ]:
2922299090

Precursor & DownStream

Precursor

  • 1-Methoxy-2,4-dinitrobenzene
  • 2,4-Dibromoanisole

DownStream

  • N-[3-(benzenecarbonothioylamino)-4-methoxyphenyl]benzenecarbothioamide
  • 1-(2-chloroethyl)-3-[5-(2-chloroethylcarbamoylamino)-2-methoxy-phenyl]urea
  • 1,7-phenanthroline-5,6-dione
  • 6-methoxyquinazolin-7-amine

Customs

[ HS Code ]: 2922299090

[ Summary ]:
2922299090. other amino-naphthols and other amino-phenols, other than those containing more than one kind of oxygen function, their ethers and esters; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

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Related Compounds

  • 4-METHOXY-1,3-BENZENEDIAMINE DIHYDROCHLORIDE
  • 4-Methoxy-1,3-benzenediamine monohydrochloride
  • 4-Methoxy-1,3-benzenediamine sulfate (1:1) hydrate
  • 4-methoxy-1,3-benzothiazol-2-amine
  • 4-Methoxy-1,3-dimethylquinolin-2(1H)-one
  • 4-methoxy-1,3-oxazolidin-2-one