Chlorohydroquinone

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Names

[ CAS No. ]:
615-67-8

[ Name ]:
Chlorohydroquinone

[Synonym ]:
1,4-Dihydroxy-2-chlorobenzene
1,4-Benzenediol, 2-chloro-
2-Chloro-1,4-benzenediol
2-chlorohydroquinone
2-Chlorbenzol-1,4-diol
2-Chloro-1,4-hydroxyquinone
CHLOROHYDROQUINONE
Hydroquinone, chloro-
2-Chlorobenzene-1,4-diol
EINECS 210-442-8
2-Chloro-1,4-dihydroxybenzene
MFCD00002341
1,4-dihydroxyl-2-chlorobenzene

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
263.0±0.0 °C at 760 mmHg

[ Melting Point ]:
100-104 °C(lit.)

[ Molecular Formula ]:
C6H5ClO2

[ Molecular Weight ]:
144.556

[ Flash Point ]:
119.7±21.8 °C

[ Exact Mass ]:
143.997803

[ PSA ]:
40.46000

[ LogP ]:
1.52

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.629

[ Water Solubility ]:
soluble

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MX4800000
CHEMICAL NAME :
Hydroquinone, chloro-
CAS REGISTRY NUMBER :
615-67-8
BEILSTEIN REFERENCE NO. :
0636835
LAST UPDATED :
199710
DATA ITEMS CITED :
8
MOLECULAR FORMULA :
C6-H5-Cl-O2
MOLECULAR WEIGHT :
144.56
WISWESSER LINE NOTATION :
L6V DVJ XG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Administration onto the skin
SPECIES OBSERVED :
Rodent - guinea pig
DOSE/DURATION :
500 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
KODAK* Kodak Company Reports. (343 State St., Rochester, NY 14650) Volume(issue)/page/year: 21MAY1971 ** REPRODUCTIVE DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Subcutaneous
DOSE :
5 mg/kg
SEX/DURATION :
female 1 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Maternal Effects - ovaries, fallopian tubes
REFERENCE :
ENDOAO Endocrinology (Baltimore). (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21203) V.1- 1917- Volume(issue)/page/year: 57,466,1955 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1141 No. of Facilities: 108 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 216 (estimated)

Safety Information

[ Symbol ]:

GHS05, GHS07

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H315-H317-H318-H335

[ Precautionary Statements ]:
P280-P305 + P351 + P338 + P310

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Faceshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S36/37-S37/39-S26

[ RIDADR ]:
UN2811

[ WGK Germany ]:
3

[ RTECS ]:
MX4800000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

Synthetic Route

Precursor & DownStream

Precursor

  • 1,4-Benzoquinone
  • 2,4-Dichlorophenol
  • 2,5-Cyclohexadiene-1,4-dione,2-chloro-
  • 2-Chlorophenol
  • 2-Chloro-4-hydroxybenzaldehyde
  • 2-nitro-4-chlorophenol
  • Hydroquinone
  • 5,6-dichlorocyclohex-2-ene-1,4-dione
  • Cycloheptatriene
  • 3-Chlorophenol

DownStream

  • 2,3-DICHLORO-5,8-DIHYDROXY-1,4-NAPHTHOQUINONE
  • Naphthazarin
  • 1,2,4-Trihydroxybenzene
  • 10-[3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl]-8-(trifluoromethyl)phenothiazin-3-ol
  • 1-chloro-2,5-diethoxy-4-nitrobenzene
  • 2,5-DICHLOROHYDROQUINONE
  • 1,4-Cyclohexanediol
  • 1,4-Cyclohexanediol
  • 4-Chloro-2,5-Dimethoxyaniline

Articles

Cytochrome P450 3A4 mediated metabolism of 2,4-dichlorophenol.

Chemosphere 34(11) , 2281-91, (1997)

The metabolism of the environmental pollutant and hepatocarcinogen 2,4-dichlorophenol (2,4-DCP) was studied using microsomal fractions and whole-cells of Saccharomyces cerevisiae containing human cyto...


More Articles


Related Compounds

  • Chlorohydroquinone dimethyl ether
  • CHLOROHYDROQUINONE di-n-PROPYL ETHER
  • 2-(Hydroxymethyl)-6-chlorohydroquinone
  • chloro-[1,4]benzoquinone, compound of chloroquinone with chlorohydroquinone
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • 4-Fluoro-6-(2,3,6-trichlorophenyl)indole
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide