protopine hydrochloride

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Names

[ CAS No. ]:
6164-47-2

[ Name ]:
protopine hydrochloride

[Synonym ]:
Bis(1,3)benzodioxolo(4,5-C:5',6'-g)azecin-13(5H)-one,4,6,7,14-tetrahydro-5-methyl-,hydrochloride
MFCD00236406
EINECS 228-196-5
Protopine HCl
7,13a-Secoberbin-13a-one,7-methyl-2,3:9,10-bis(methylenedioxy)-,hydrochloride
Protopine,hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
547.5ºC at 760 mmHg

[ Melting Point ]:
208ºC

[ Molecular Formula ]:
C20H20ClNO5

[ Molecular Weight ]:
389.83

[ Flash Point ]:
284.9ºC

[ Exact Mass ]:
389.10300

[ PSA ]:
57.23000

[ LogP ]:
3.29720

[ Storage condition ]:
2-8°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
UL2000000
CHEMICAL NAME :
Protopine, hydrochloride
CAS REGISTRY NUMBER :
6164-47-2
LAST UPDATED :
199012
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C20-H19-N-O5.Cl-H
MOLECULAR WEIGHT :
389.86
WISWESSER LINE NOTATION :
T I5 G6 B-10-65 DN JO LO PV VO A&O KH WH&&T&&J D1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
102 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 104,253,1952
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
36 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
FEPRA7 Federation Proceedings, Federation of American Societies for Experimental Biology. (Bethesda, MD) V.1-46, 1942-87. Volume(issue)/page/year: 5,163,1946

Safety Information

[ Symbol ]:

GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H301

[ Precautionary Statements ]:
P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges

[ Hazard Codes ]:
T

[ Risk Phrases ]:
25

[ Safety Phrases ]:
36/37/39-45

[ RIDADR ]:
UN 1544

[ RTECS ]:
UL2000000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1(b)

Articles

Antidiabetic effects of the Cimicifuga racemosa extract Ze 450 in vitro and in vivo in ob/ob mice.

Phytomedicine 21(11) , 1382-9, (2014)

It was the aim of the present experiments to examine potential antidiabetic effects of the Cimicifuga racemosa extract Ze 450.Ze 450 and some of its components (23-epi-26-deoxyactein, protopine and ci...

Design and evaluation of self-emulsifying drug delivery systems of Rhizoma corydalis decumbentis extracts.

Drug Dev. Ind. Pharm. 38(10) , 1200-6, (2012)

To improve the dissolution and oral absorption of Rhizoma corydalis decumbentis extracts (RCDE), a famous traditional Chinese herbal medicine which contains poorly water-soluble active components, sel...

Optimization of microwave-assisted extraction of protopine and allocryptopine from stems of Macleaya cordata (Willd) R. Br. using response surface methodology.

J. Sep. Sci. 33(14) , 2160-7, (2010)

The purpose of the research was to investigate the multiple response optimizations for the extraction of protopine and allocryptopine from the stems of Macleaya cordata (Willd) R. Br. by using microwa...


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Related Compounds

  • Tyrocidine, hydrochloride
  • Triprolidine hydrochloride
  • Minoxidil hydrochloride
  • Elacridar hydrochloride
  • dodecylamine hydrochloride
  • Azetidine, hydrochloride, homopolymer (9CI)
  • 5-((Isopropyl(methyl)amino)methyl)pyridin-2-amine
  • 1-Methyl-1-(pyridin-3-yl)thiourea
  • 2-(5-Methylthiophen-2-yl)cyclohexan-1-ol
  • 5-(1-Methyl-propenyl)-pyridin-2-ylamine
  • 5-[(4-Methoxy-1-piperidinyl)methyl]-2-pyridinamine
  • 7-(Ethylmethylamino)-5-methylpyrazolo[1,5-a]pyrimidine-3-carboxylic acid
  • 5-Isopropoxy-6-methoxy-pyridine-2-carboxylic acid
  • 4-(Ethanesulfonyl)-3-methylbenzoic acid
  • 3-Fluoro-4-(2-hydroxy-2-methyl-propyl)benzoic acid
  • (RS)-5-(3-iodo-phenyl)-5-methyl-morpholin-3-one
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