5-Hepten-2-amine,N,6-dimethyl-, hydrochloride (1:1)

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Names

[ Name ]:
5-Hepten-2-amine,N,6-dimethyl-, hydrochloride (1:1)

[Synonym ]:
Isometheptene hydrochloride
EINECS 228-211-5
Methylamino-methylheptene hydrochloride
Isometheptene HCl
4-HEXENYLAMINE,N,1,5-TRIMETHYL-,HYDROCHLORIDE
(1,5-Dimethylhex-4-enyl)methylammonium chloride
Isomethepdrine chloride
2-Methylaminoisooctane hydrochloride

Chemical & Physical Properties

[ Boiling Point ]:
177.5ºC at 760 mmHg

[ Molecular Formula ]:
C₉H₂₀ClN

[ Molecular Weight ]:
177.71500

[ Flash Point ]:
46.4ºC

[ Exact Mass ]:
177.12800

[ PSA ]:
16.61000

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: MP9625000

CHEMICAL NAME :: 4-Hexenylamine, N,1,5-trimethyl-, hydrochloride

CAS REGISTRY NUMBER :: 6168-86-1

LAST UPDATED :: 199012

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C9-H19-N.Cl-H

MOLECULAR WEIGHT :: 177.75

WISWESSER LINE NOTATION :: 1Y1&U3Y1&M1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 70 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Behavioral - excitement

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 81,235,1944

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 71,62,1941

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 171 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,214,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Behavioral - convulsions or effect on seizure threshold

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,214,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 76 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,214,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 26 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - excitement Lungs, Thorax, or Respiration - other changes

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,214,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 101 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,214,1948

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 18 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 92,214,1948

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Amphibian - frog

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Behavioral - excitement Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: QJPPAL Quarterly Journal of Pharmacy & Pharmacology. (London, UK) V.2-21, 1929-48. For publisher information, see JPPMAB. Volume(issue)/page/year: 9,647,1936

Related Compounds

1-(1-Cyclopropylpyrazol-3-yl)ethanone
2-(2,3-Dimethylphenyl)-5-methyl-1H-imidazole
2-(2-Propan-2-yloxyethylamino)pyrimidine-5-carboxylic acid
2-(4-Ethynylphenyl)-2-methylpropan-1-ol
1-(1,3-dimethoxypropan-2-yl)-1H-pyrazol-4-amine
1-(Ethanesulfonyl)-1H-pyrazol-4-amine
1-(2-methoxycyclopentyl)-1H-pyrazol-4-amine
1-(2-methylprop-2-en-1-yl)-1H-pyrazol-4-amine
4-Methyl-1-(1-methylpiperidin-4-yl)-1h-pyrazol-3-amine
3-Methyl-1-(pyrimidin-2-ylmethyl)-1h-pyrazol-4-amine

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