Oxaliplatin

Suppliers

Names

[ CAS No. ]:
61825-94-3

[ Name ]:
Oxaliplatin

[Synonym ]:
Dacplat
Oxaliplatin
MFCD00866327
platinum, [ethanedioato(2-)-κO,κO]-, compd. with (1R,2R)-1,2-cyclohexanediamine (1:1)
Platinum(2+) ethanedioate - (1R,2R)-1,2-cyclohexanediamine (1:1)
Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1)
[Ethanedioato(2-)-κO,O]platinum - (1R,2R)-cyclohexane-1,2-diamine (1:1)
Platinum(2+) ethanedioate (1R,2R)-1,2-cyclohexanediamine (1:1:1)
Elocatin

Chemical & Physical Properties

[ Boiling Point ]:
193.6ºC at 760 mmHg

[ Molecular Formula ]:
C8H12N2O4Pt

[ Molecular Weight ]:
395.28

[ PSA ]:
104.64000

[ LogP ]:
0.61450

[ Appearance of Characters ]:
solid

[ Storage condition ]:
Store at +4°C

[ Stability ]:
Stable. Store cool. Incompatible with oxidizing agents.

[ Water Solubility ]:
Slightly soluble in water, very slightly soluble in methanol, practically insoluble in anhydrous ethanol. | Soluble in water with heating and/or sonication

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TP2275850
CHEMICAL NAME :
Platinum, (1,2-cyclohexanediamine-N,N')(ethanedioato(2-)-O,O')- , (SP-4-2-(1R-trans))-
CAS REGISTRY NUMBER :
61825-94-3
LAST UPDATED :
199706
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H14-N2-O4-Pt
MOLECULAR WEIGHT :
397.33

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
14300 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,529,1989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
19800 ug/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 14,529,1989

Safety Information

[ Symbol ]:

GHS07, GHS08

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H317-H319-H335-H351

[ Precautionary Statements ]:
P261-P280-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
Xn:Harmful;

[ Risk Phrases ]:
R36/37/38;R40;R42/43

[ Safety Phrases ]:
S26-S36

[ RIDADR ]:
UN 2811 6.1/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
TP2275850

[ Packaging Group ]:
II

[ HS Code ]:
28439000

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Potassium tetrachloroplatinate(II)
  • (1R,2R)-(-)-1,2-Diaminocyclohexane
  • Oxalic acid
  • trans(−)-DDCP
  • disilver(I) oxalate
  • ditetrabutylammonium oxolate

DownStream

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Related Compounds

  • Oxaliplatin
  • (S,S)-Oxaliplatin
  • Oxaliplatin impurity C
  • Dihydroxy Oxaliplatin-Pt(IV)
  • Oxaliplatin mixture with capecitabine
  • 5-Chloro-4-acetamido-2-fluorobenzene-1-sulfonyl fluoride
  • 3-Formamido-4-methylheptanoic acid
  • 4-[2-({[(9H-fluoren-9-yl)methoxy]carbonyl}amino)-3,3-dimethylbutanamido]-3-methylbutanoic acid
  • 2-{Imidazo[1,2-a]pyridin-2-yloxy}ethan-1-amine
  • 1-Amino-2,4,6-trimethylheptan-3-ol
  • 3-(Aminomethyl)-1-methoxyhexan-2-ol
  • 5-Amino-1-(5-fluoropentyl)-1,2,3,4-tetrahydropyrimidine-2,4-dione
  • 3-Iodo-4-(propan-2-yl)cyclohexan-1-one
  • 2-(2-Methylbutan-2-yl)-5-oxocyclohexane-1-carboxylic acid
  • Methyl 2-ethyl-5,5-dimethyl-1-oxaspiro[2.3]hexane-2-carboxylate
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