trans(−)-DDCP

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Names

[ CAS No. ]:
61848-66-6

[ Name ]:
trans(−)-DDCP

[Synonym ]:
MFCD00058826

Chemical & Physical Properties

[ Boiling Point ]:
193.6ºC at 760mmHg

[ Melting Point ]:
>256°C (dec.)

[ Molecular Formula ]:
C6H12Cl2N2Pt

[ Molecular Weight ]:
378.15700

[ Flash Point ]:
75ºC

[ Exact Mass ]:
377.00300

[ PSA ]:
24.06000

[ LogP ]:
2.43950

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TP2275980
CHEMICAL NAME :
Platinum(II), (cyclohexane-1,2-diammine)dichloro-, (E)-(-)-
CAS REGISTRY NUMBER :
61848-66-6
LAST UPDATED :
199410
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C6-H14-Cl2-N2-Pt
MOLECULAR WEIGHT :
380.21

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
20530 ug/kg/10W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors
TYPE OF TEST :
TD - Toxic dose (other than lowest)
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
41060 ug/kg/10W-I
TOXIC EFFECTS :
Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors

MUTATION DATA

TYPE OF TEST :
Mutation test systems - not otherwise specified
TEST SYSTEM :
Bacteria - Bacillus subtilis
DOSE/DURATION :
13 umol/L/3H (Continuous)
REFERENCE :
CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 41,4368,1981

Safety Information

[ Hazard Codes ]:
Xn

[ RIDADR ]:
3467.0

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Potassium tetrachloroplatinate(II)
  • (1R,2R)-(-)-1,2-Diaminocyclohexane
  • (R,R)-(-)-1,2-Diaminocyclohexane
  • {Pt(trans-(R,R-1,2-diaminocyclohexane))(ascorbato-C(2),O(5))}methanesulfonate
  • CHLORIDE STANDARD
  • {PtCl(dimethyl sulfoxide) (R,R-1,2-diaminocyclohexane)}NO3

DownStream

  • Oxaliplatin

Related Compounds

  • (trans,trans)-4'-Heptyl-[1,1'-bicyclohexyl]-4-ol
  • trans-3-(trimethylsilyl)acryl-aldehyde
  • trans-3-methylcyclohexanol
  • trans-1-benzoyl-2,3-diphenylaziridine
  • trans-pinocarvyl acetate
  • trans-4-Trifluoromethyl-cyclohexylamine hydrochloride
  • N-(1-(3-methoxyphenyl)-5-oxopyrrolidin-3-yl)-4-methylbenzenesulfonamide
  • 4-chloro-N-(1-(3-methoxyphenyl)-5-oxopyrrolidin-3-yl)benzenesulfonamide
  • 4-fluoro-N-[1-(3-methoxyphenyl)-5-oxopyrrolidin-3-yl]benzene-1-sulfonamide
  • N-[1-(3-methoxyphenyl)-5-oxopyrrolidin-3-yl]naphthalene-2-sulfonamide
  • N-(1-(3-methoxyphenyl)-5-oxopyrrolidin-3-yl)-2,4,6-trimethylbenzenesulfonamide
  • N-(1-(3-methoxyphenyl)-5-oxopyrrolidin-3-yl)-2,3-dihydrobenzo[b][1,4]dioxine-6-sulfonamide
  • 4-methoxy-N-(1-(3-methoxyphenyl)-5-oxopyrrolidin-3-yl)-3-methylbenzenesulfonamide
  • 2,5-dimethoxy-N-(1-(3-methoxyphenyl)-5-oxopyrrolidin-3-yl)benzenesulfonamide
  • 4-chloro-N-(1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl)benzenesulfonamide
  • 4-fluoro-N-(1-(4-methoxyphenyl)-5-oxopyrrolidin-3-yl)benzenesulfonamide
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