2-bromo-4'-methylacetophenone

Names

[ CAS No. ]:
619-41-0

[ Name ]:
2-bromo-4'-methylacetophenone

[Synonym ]:
Ethanone, 2-bromo-1-(4-methylphenyl)-
2-bromo-4'-methylacetophenone
EINECS 226-267-5
2-Bromo-1-(4-methylphenyl)ethanone
MFCD00009312
Acetophenone, 2-bromo-4'-methyl-

Chemical & Physical Properties

[ Density]:
1.4±0.1 g/cm3

[ Boiling Point ]:
263.6±15.0 °C at 760 mmHg

[ Melting Point ]:
45-49 °C(lit.)

[ Molecular Formula ]:
C₉H₉BrO

[ Molecular Weight ]:
213.071

[ Flash Point ]:
74.4±7.7 °C

[ Exact Mass ]:
211.983673

[ PSA ]:
17.07000

[ LogP ]:
2.65

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.563

[ Storage condition ]:
-20?C Freezer, Under Inert Atmosphere

[ Stability ]:
Stable. Incompatible with strong oxidizing agents, strong bases.

MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S27-S37/39

[ RIDADR ]:
UN 2811

[ WGK Germany ]:
3

[ Hazard Class ]:
6.1

[ HS Code ]:
2914700090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

4'-Methylacetophenone
2,2-Dibromo-4'-methylacetophenone
4-Methylstyrene
Bromoacetyl bromide
Toluene
(±)-2-bromo-1-(4-methylphenyl)ethan-1-ol
1-(4-Methylphenyl)ethanol
4-Ethynyltoluene

DownStream

BENZENEACETALDEHYDE, 4-METHYL-.ALPHA.-OXO-
1-(4-methylphenyl)-2-(1,2,4-triazol-1-yl)prop-2-en-1-one
2-(4-Methylphenyl)-2-oxoethanaminiumchlorid
1-(4-bromophenyl)-2-hydroxyethan-1-one
1-(4-Methylphenyl)ethylamine
2-P-TOLYLIMIDAZO[1,2-A]PYRIDINE-3-CARBALDEHYDE
2-phenylquinazolin-4-ol
4-methylbenzoyl cyanide
2-benzyl-4(3H)-quinazolinone
6-chloro-2-p-tolylimidazo[1,2-a]pyrimidine

Customs

[ HS Code ]: 2914700090

[ Summary ]:
HS: 2914700090 halogenated, sulphonated, nitrated or nitrosated derivatives of ketones and quinones, whether or not with other oxygen function Tax rebate rate:9.0% Supervision conditions:none VAT:17.0% MFN tariff:5.5% General tariff:30.0%

Articles

Efficient solid-phase synthesis of 2-substituted-3-hydroxy-4(1H)-quinolinone-7-carboxamides with two diversity positions.

J. Comb. Chem. 9(5) , 793-6, (2007)

A highly efficient solid-phase synthesis of 2-substituted-3-hydroxy-4(1H)-quinolinone-7-carboxamides was developed using anthranilates and bromoketones as the key synthons. Primary amines immobilized ...

Use of fluorous silica gel to separate fluorous thiol quenching derivatives in solution-phase parallel synthesis Zhang W, et al.

Tetrahedron 58(20) , 3871-75, (2002)

2-bromo-1-(2,3-difluoro-4-methylphenyl)ethanone
2-bromo-4'-hydroxyphenyl acetic acid
(2-BROMO-4'-TRIFLUOROMETHYL-BIPHENYL-4-YL)-ACETIC ACID METHYL ESTER
2-Bromo-4'-hydroxyacetophenone
2-Bromo-4'-(2,2-difluoro-1-trifluoromethyl-vinyl)-4-methyl-biphenyl
2-Bromo-4'-hydroxy-3'-nitropropiophenone
4-Bromo-2-hydroxy-3-(2-thiazolidinyl)benzoic acid
1,1-Dimethoxybutan-2-amine
6-Amino-5-chloro-N-[(1S)-1-[5-[[[5-chloro-4-(trifluoromethyl)-2-pyridinyl]amino]carbonyl]-2-thiazolyl]ethyl]-4-pyrimidinecarboxamide
2-(3-aminophenyl)-N-(2-morpholin-4-ylethyl)acetamide
2-(3-Aminophenyl)-1-(4-ethyl-1-piperazinyl)ethanone
2-(3-aminophenyl)-N-benzylacetamide
2-(3-aminophenyl)-N-(pyridin-2-ylmethyl)acetamide
3-Methoxy-4-pyridin-2-ylbenzaldehyde
N-[3-Oxo-3-(1-piperazinyl)propyl]acetamide
N-[3-Oxo-3-(1-piperazinyl)propyl]methanesulfonamide

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