Cinnamic acid

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Names

[ CAS No. ]:
621-82-9

[ Name ]:
Cinnamic acid

[Synonym ]:
(E)-3-Phenylprop-2-enoic acid
Propenoic acid, 3-phenyl-, (trans)-
Cinnamic acid
(2E)-3-Phenylacrylic acid
trans-Cinnamic Acid
EINECS 205-398-1
MFCD00004369
QV1U1R &&Trans or E Form
2-Propenoic acid, 3-phenyl-, (2E)-
4-09-00-02002 (Beilstein Handbook Reference)
trans-b-Carboxystyrene
2-Propenoicacid, 3-phenyl-

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
265.0±0.0 °C at 760 mmHg

[ Melting Point ]:
133ºC

[ Molecular Formula ]:
C₉H₈O₂

[ Molecular Weight ]:
148.159

[ Flash Point ]:
189.5±9.6 °C

[ Exact Mass ]:
148.052429

[ PSA ]:
37.30000

[ LogP ]:
2.41

[ Vapour Pressure ]:
0.0±0.5 mmHg at 25°C

[ Index of Refraction ]:
1.616

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GD7800000

CHEMICAL NAME :: Cinnamic acid

CAS REGISTRY NUMBER :: 621-82-9

LAST UPDATED :: 199701

DATA ITEMS CITED :: 9

MOLECULAR FORMULA :: C9-H8-O2

MOLECULAR WEIGHT :: 148.17

WISWESSER LINE NOTATION :: QV1U1R

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,687,1978 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2500 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,687,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: BCFAAI Bollettino Chimico Farmaceutico. (Societa Editoriale Farmaceutica, Via Ausonio 12, 20123 Milan, Italy) V.33- 1894- Volume(issue)/page/year: 112,53,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GISAAA Gigiena i Sanitariya. For English translation, see HYSAAV. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1- 1936- Volume(issue)/page/year: 46(1),94,1981

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 160 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 16,687,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 19,617,1969

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - guinea pig

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: VPITAR Voprosy Pitaniya. Problems of Nutrition. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-10, 1932-41; V.11- 1952- Volume(issue)/page/year: 33(5),48,1974 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82933 No. of Facilities: 87 (estimated) No. of Industries: 2 No. of Occupations: 10 No. of Employees: 22012 (estimated)

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
26-36

[ WGK Germany ]:
1

[ RTECS ]:
GD7850000

[ HS Code ]:
2916190090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Cinnamyl alcohol
Iodobenzene
Acrylic acid
Bromobenzene
Carbon dioxide
Benzaldehyde
acetic acid
Cinnamaldehyde
butyl acrylate

DownStream

3-chloro-N-methyl-N-phenyl-1-benzothiophene-2-carboxamide
3-phenylprop-2-enoyl bromide
rac 5-Carboxy Tolterodine
3-(3-phenylprop-2-enoyl)-1,3-oxazolidin-2-one
3,3-Diphenylpropanoic acid
3-Phenyl-1-indanone
6-CARBOXYL-4-PHENYL-3,4-DIHYDROCOUMARIN
4-(2-OXO-2-PHENYLETHYL)BENZOIC ACID
3-(2-Hydroxyphenyl)propionate
Sodium (2E)-3-phenylacrylate

Customs

[ HS Code ]: 2916399090

[ Summary ]:
2916399090 other aromatic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

Related Compounds

Cinnamic acid
cis-cinnamic acid
Cinnamic acid-13C3
3-Bromocinnamic acid
p-Ethylcinnamic acid
α-iodo-cinnamic acid
5-(4-(tert-Butyl)phenyl)oxazole-2-carboxylic acid
3-Amino-N-ethyl-4-(pyrrolidin-1-yl)benzamide
5-(1-phenyl-1H-pyrazol-4-yl)-1H-imidazol-2-amine
5-(tert-Butyl)-2-methoxybenzenesulfonic acid
1-(4-Methylphenyl)-4-oxo-1,4-dihydrocinnoline-3-carboxylic acid
Tert-butyl {[1-(2-chlorophenyl)-5-(pyridin-3-ylsulfonyl)-1h-pyrazol-3-yl]methyl}methylcarbamate
4-(1,3-Benzodioxol-5-ylmethyl)-1-piperazinecarboxaldehyde
1-(5-Chloroisoquinolin-1-yl)ethanol
5-(5-(Methylsulfonyl)pyridin-3-yl)thiazolo[5,4-b]pyridin-2-amine
N4-isopropyl-N6-methylpyrimidine-4,6-diamine

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