Rauwolscine hydrochloride
Suppliers
Names
[ CAS No. ]:
6211-32-1
[ Name ]:
Rauwolscine hydrochloride
[Synonym ]:
isoyohimbine
20α-Yohimban-16β-carboxylic acid, 17α-hydroxy-, methyl ester, monohydrochloride (8CI)
EINECS 228-279-6
rauwolscine
Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (15ξ,16β,17α,20α)-, hydrochloride (1:1)
Methyl (15ξ,16β,17α,20α)-17-hydroxyyohimban-16-carboxylate hydrochloride (1:1)
Methyl (1S,2S,4aS,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoline-1-carboxylate hydrochloride
Methyl-(1S,2S,4aS,13bS,14aS)-2-hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodecahydroindolo[2',3':3,4]pyrido[1,2-b]isochinolin-1-carboxylathydrochlorid
mesoyohimbine
Methyl (16β,17α,20α)-17-hydroxyyohimban-16-carboxylate hydrochloride (1:1)
Methyl (16β,17α,20α)-17-hydroxyyohimban-16-carboxylate hydrochloride
(16β,17α,20α)-17-Hydroxyyohimban-16-carboxylate de méthyle chlorhydrate
rauwolfscine hydrochloride
20α-Yohimban-16β-carboxylic acid, 17α-hydroxy-, methyl ester, monohydrochloride
Methyl-(16β,17α,20α)-17-hydroxyyohimban-16-carboxylathydrochlorid
(1S,2S,4aS,13bS,14aS)-2-Hydroxy-1,2,3,4,4a,5,7,8,13,13b,14,14a-dodécahydroindolo[2',3':3,4]pyrido[1,2-b]isoquinoléine-1-carboxylate de méthyle chlorhydrate
rauwolscine hcl
Yohimban-16-carboxylic acid, 17-hydroxy-, methyl ester, (16β,17α,20α)-, hydrochloride (1:1)
Rauwolscine (hydrochloride)
Chemical & Physical Properties
[ Density]:
1.31 g/cm3
[ Boiling Point ]:
543ºC at 760 mmHg
[ Melting Point ]:
270-280ºC
[ Molecular Formula ]:
C21H27ClN2O3
[ Molecular Weight ]:
390.904
[ Flash Point ]:
282.2ºC
[ Exact Mass ]:
390.171021
[ PSA ]:
65.56000
[ LogP ]:
3.38700
[ Storage condition ]:
Store at RT
[ Water Solubility ]:
H2O: soluble
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- ZG1035000
- CHEMICAL NAME :
- 20-alpha-Yohimban-16-beta-carboxylic acid, 17-alpha-hydroxy-, methyl ester, hydrochloride
- CAS REGISTRY NUMBER :
- 6211-32-1
- LAST UPDATED :
- 199203
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C21-H26-N2-O3.Cl-H
- MOLECULAR WEIGHT :
- 390.95
- WISWESSER LINE NOTATION :
- T F6 D5 C666 EM ON&&TTTJ TQ UVO1 &GH
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 125 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- REFERENCE :
- LDBU** "Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J., Institute fuer Pharmakologie und Experimentelle Therapie der Universitat Breslau, Poland, 1932 Volume(issue)/page/year: -,-,1932
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 20 mg/kg
- TOXIC EFFECTS :
- Behavioral - general anesthetic Behavioral - muscle contraction or spasticity Lungs, Thorax, or Respiration - dyspnea
- REFERENCE :
- LDBU** "Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J., Institute fuer Pharmakologie und Experimentelle Therapie der Universitat Breslau, Poland, 1932 Volume(issue)/page/year: -,-,1932
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- LDBU** "Zur Pharmakologie der Yohimbealkaloide, Dissertation," Langer, J., Institute fuer Pharmakologie und Experimentelle Therapie der Universitat Breslau, Poland, 1932 Volume(issue)/page/year: -,-,1932
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 162 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BSPHAV Bulletin des Sciences Pharmacologiques. (Paris, France) V.1-49, 1899-1942. For publisher information, see APFRAD. Volume(issue)/page/year: 47,33,1940
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BSPHAV Bulletin des Sciences Pharmacologiques. (Paris, France) V.1-49, 1899-1942. For publisher information, see APFRAD. Volume(issue)/page/year: 47,33,1940
Safety Information
[ Hazard Codes ]:
T: Toxic;
[ Risk Phrases ]:
R23/24/25
[ Safety Phrases ]:
22-36/37/39-45
[ RIDADR ]:
UN 1544 6
[ WGK Germany ]:
3
[ RTECS ]:
ZG1035000
[ HS Code ]:
29339900