1-(4-Methylphenyl)thiourea

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Names

[ CAS No. ]:
622-52-6

[ Name ]:
1-(4-Methylphenyl)thiourea

[Synonym ]:
MFCD00041190
EINECS 210-740-8
Thiourea, N-(4-methylphenyl)-
(4-methylphenyl)thiourea
1-(4-Methylphenyl)thiourea

Chemical & Physical Properties

[ Density]:
1.2±0.1 g/cm3

[ Boiling Point ]:
282.5±33.0 °C at 760 mmHg

[ Melting Point ]:
186 °C

[ Molecular Formula ]:
C8H10N2S

[ Molecular Weight ]:
166.243

[ Flash Point ]:
124.7±25.4 °C

[ Exact Mass ]:
166.056473

[ PSA ]:
70.14000

[ LogP ]:
1.19

[ Vapour Pressure ]:
0.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.696

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
YU3325000
CHEMICAL NAME :
Urea, 2-thio-1-p-tolyl-
CAS REGISTRY NUMBER :
622-52-6
LAST UPDATED :
199012
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C8-H10-N2-S
MOLECULAR WEIGHT :
166.26
WISWESSER LINE NOTATION :
SUYZMR D1

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
5 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,45,1953
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
100 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
JMPCAS Journal of Medicinal and Pharmaceutical Chemistry. (Washington, DC) V.1-5, 1959-62. For publisher information, see JMCMAR. Volume(issue)/page/year: 4,147,1961

Safety Information

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
R25

[ Safety Phrases ]:
S20-S36-S45-S60

[ RIDADR ]:
2811

[ RTECS ]:
YU3325000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2930909090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • p-Toluidine
  • 4-Methylphenyl isothiocyanate
  • Urea, 1-benzoyl-2-thio-3-p-tolyl-
  • 4-Methylaniline hydrochloride
  • Potassium thiocyanate
  • 2-Amino-5-methylbenzoic acid
  • p-tolyldithiocarbamic acid triethylamine salt
  • (4-methylphenyl)cyanamide
  • N-(4-methylphenyl)-dithiocarbamic acid methyl ester

DownStream

  • (4-methylphenyl)cyanamide
  • Urea,N,N'-bis(4-methylphenyl)-
  • 2-chloro-N-(6-methyl-1,3-benzothiazol-2-yl)acetamide
  • 6-amino-1-(4-methylphenyl)-2-sulfanylidenepyrimidin-4-one
  • 4-methylformanilide
  • N,N'-bis(4-methylphenyl)methanimidamide
  • p-Toluidine
  • 1-(4-methylphenyl)-2-sulfanylidene-1,3-diazinane-4,6-dione
  • 2,4-Thiazolidinedione
  • FMOC-3,5-DIBROMO-D-TYROSINE

Customs

[ HS Code ]: 2930909090

[ Summary ]:
2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Related Compounds

  • 3-aMino-1-(4-Methylphenyl)thiourea
  • 1-amino-1-(4-methylphenyl)thiourea
  • 1-methyl-1-(4-methylphenyl)thiourea
  • 1-Carbamimidoyl-1-(4-methylphenyl)thiourea
  • 1-buta-2,3-dienyl-1-(4-methylphenyl)thiourea
  • 1-[(E)-N'-[(E)-butan-2-ylideneamino]carbamimidoyl]-1-(4-methylphenyl)thiourea,hydrochloride