Methyl (2E)-2-butenoate
Suppliers
Names
[ CAS No. ]:
623-43-8
[ Name ]:
Methyl (2E)-2-butenoate
[Synonym ]:
Methyl-(2E)-but-2-enoat
methyl-trans-3-triethylsilylacrylate
methyl trans-crotonate
Crotonic acid, methyl ester
EINECS 210-793-7
Methyl (2E)-but-2-enoate
Methyl Crotonate
methyl-trans-4-oxo-2-pentoate
E-1-triethylsilylpropensaeuremethylester
2-Butenoic acid, methyl ester
crotonic acid methyl ester
2-Butenoic acid, methyl ester, (2E)-
Methyl (2E)-2-butenoate
Crotonic acid, methyl ester (8CI)
MFCD00009287
3-methyl-acrylic acid,methyl ester
Chemical & Physical Properties
[ Density]:
0.9±0.1 g/cm3
[ Boiling Point ]:
121.0±0.0 °C at 760 mmHg
[ Molecular Formula ]:
C5H8O2
[ Molecular Weight ]:
100.116
[ Flash Point ]:
4.4±0.0 °C
[ Exact Mass ]:
100.052429
[ PSA ]:
26.30000
[ LogP ]:
1.32
[ Vapour Pressure ]:
14.9±0.2 mmHg at 25°C
[ Index of Refraction ]:
1.414
[ Water Solubility ]:
IMMISCIBLE
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- GQ5710000
- CHEMICAL NAME :
- Crotonic acid, methyl ester, (E)-
- CAS REGISTRY NUMBER :
- 623-43-8
- BEILSTEIN REFERENCE NO. :
- 1720292
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 7
- MOLECULAR FORMULA :
- C5-H8-O2
- MOLECULAR WEIGHT :
- 100.13
- WISWESSER LINE NOTATION :
- 2U1VO1
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979 ** ACUTE TOXICITY DATA **
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >3200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979
- TYPE OF TEST :
- LC - Lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >19000 ppm/6H
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1600 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Administration onto the skin
- SPECIES OBSERVED :
- Rodent - guinea pig
- DOSE/DURATION :
- 10 mL/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- FCTXAV Food and Cosmetics Toxicology. (London, UK) V.1-19, 1963-81. For publisher information, see FCTOD7. Volume(issue)/page/year: 17,865,1979
Safety Information
[ Symbol ]:
GHS02, GHS07
[ Signal Word ]:
Danger
[ Hazard Statements ]:
H225-H315-H319-H335
[ Precautionary Statements ]:
P210-P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
F:Flammable;Xi:Irritant;
[ Risk Phrases ]:
R11;R36/37/38
[ Safety Phrases ]:
S16-S26-S36-S33-S9
[ RIDADR ]:
UN 3272 3/PG 2
[ WGK Germany ]:
2
[ RTECS ]:
GQ5710000
[ Packaging Group ]:
II
[ Hazard Class ]:
3.0
[ HS Code ]:
29161980
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2916190090
[ Summary ]:
2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0%
Articles
J. Org. Chem. 67(17) , 5969-76, (2002)
The phytotoxins solanapyrones D (1) and E (2) have been synthesized from the decalone prepared by the domino Michael reaction of the kinetic enolate of optically pure acetylcyclohexene with methyl cro...
Org. Lett. 14(11) , 2678-81, (2012)
The synthesis of the novel Lewis acid, aluminum tris(2,6-di-2-naphthylphenoxide) (ATNP), and its use in the vinylogous aldol reaction between methyl crotonate and enolizable aldehydes are described. A...
Solvent engineering: an effective tool to direct chemoselectivity in a lipase-catalyzed Michael addition. Priego J, et al.Tetrahedron 65(2) , 536-539, (2009)