Ethyl iodoacetate

Suppliers

Names

[ CAS No. ]:
623-48-3

[ Name ]:
Ethyl iodoacetate

[Synonym ]:
ETHYL IODOACETATE
Ethyl monoiodoacetate
MFCD00001081
Acetic acid,iodo-,ethyl ester
Iodoacetic acid,ethyl ester
EINECS 210-796-3

Chemical & Physical Properties

[ Density]:
1.808 g/mL at 25 °C(lit.)

[ Boiling Point ]:
179-180 °C(lit.)

[ Molecular Formula ]:
C4H7IO2

[ Molecular Weight ]:
214.00200

[ Flash Point ]:
170 °F

[ Exact Mass ]:
213.94900

[ PSA ]:
26.30000

[ LogP ]:
0.98450

[ Index of Refraction ]:
n20/D 1.503(lit.)

[ Storage condition ]:
2-8°C

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AI3575000
CHEMICAL NAME :
Acetic acid, iodo-, ethyl ester
CAS REGISTRY NUMBER :
623-48-3
BEILSTEIN REFERENCE NO. :
0741934
LAST UPDATED :
199710
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C4-H7-I-O2
MOLECULAR WEIGHT :
214.01
WISWESSER LINE NOTATION :
I1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: 0TS0570989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
10 mg/kg
TOXIC EFFECTS :
Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold Skin and Appendages - hair
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: 0TS0570989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
50 mg/kg
TOXIC EFFECTS :
Behavioral - altered sleep time (including change in righting reflex) Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: 0TS0570989
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
45 mg/kg
TOXIC EFFECTS :
Autonomic Nervous System - other (direct) parasympathomimetic Lungs, Thorax, or Respiration - other changes Nutritional and Gross Metabolic - other changes
REFERENCE :
JNCIAM Journal of the National Cancer Institute. (Washington, DC) V.1-60, 1940-78. For publisher information, see JJIND8. Volume(issue)/page/year: 31,297,1963

Safety Information

[ Symbol ]:

GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H314

[ Precautionary Statements ]:
P264-P280-P301 + P310-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T: Toxic;

[ Risk Phrases ]:
R25;R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 2922 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
AI3575000

[ Packaging Group ]:
II

[ Hazard Class ]:
6.1

[ HS Code ]:
2915900090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • ethyl 2-bromoacetate
  • Ethyl (trimethylsilyl)acetate
  • Phenyl 2-chloroacetate
  • Ethyl fluoroacetate
  • ethyl 2-triphenylstannylacetate
  • ethyl chloroacetate
  • Ethanol
  • Iodoacetic acid
  • ethyl-(1,1-difluoro-2-iodo-ethyl)-ether
  • diiodoacetylene

DownStream

  • (+)-2,2-DIMETHYL-4,5-((DIPHENYLPHOSPHINO)DIMETHYL)DIOXOLANE
  • (-)-Ethyl (S)-3-hydroxy-3-phenylpropionate
  • ETHYL-3-HYDROXY-3-PHENYL PROPIONATE
  • ethyl 2-(3-nitro-2-oxopyridin-1-yl)acetate
  • 3-(4-methylphenyl)but-2-enoic acid
  • Ethyl fluoroacetate
  • ethyl 2-iodo-3-phenylprop-2-enoate
  • (E)-3-(4-methoxyphenyl)but-2-enoic acid
  • Ethyl 4-oxopentanoate
  • Ethyl 2-ethoxyacetate

Customs

[ HS Code ]: 2915900090

[ Summary ]:
2915900090 other saturated acyclic monocarboxylic acids and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:5.5% General tariff:30.0%

Articles

Synthesis of a leucomitosane via a diastereoselective radical cascade.

J. Org. Chem. 78(12) , 6245-52, (2013)

The preparation of trans-2,3-disubstituted indolines from 1-azido-2-allylbenzene derivatives via a diastereoselective radical cascade using ethyl iodoacetate and triethylborane is described. Further l...


More Articles

Related Compounds

  • 2-(trimethylsilyl)ethyl iodoacetate
  • 2-[(2-chloroethyl)(phenyl)amino]ethyl iodoacetate
  • ethyl 2-bromo-2-iodoacetate
  • ETHYL 5-OXO-5-(4-TRIFLUOROMETHYLPHENYL)VALERATE
  • ETHYL 2-((TERT-BUTOXYCARBONYL)AMINO)THIAZOLE-5-CARBOXYLATE
  • ethyl 2-(2-phenylethynyl)benzoate
  • N-(3-acetamidophenyl)-2-((1-(3-morpholinopropyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
  • N-(2-fluorophenyl)-2-((1-(3-morpholinopropyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
  • 2-((1-(3-morpholinopropyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(o-tolyl)acetamide
  • N-(4-fluorophenyl)-2-((1-(3-morpholinopropyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
  • N-(3-chlorophenyl)-2-((1-(3-morpholinopropyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
  • methyl 4-(2-((1-(3-morpholinopropyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamido)benzoate
  • N-(4-acetylphenyl)-2-((1-(3-morpholinopropyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)acetamide
  • N-(3-(benzo[d]thiazol-2-yl)-4,5-dimethylthiophen-2-yl)-3-tosylpropanamide
  • 4-((2-(indolin-1-yl)-2-oxoethyl)thio)-1-(3-morpholinopropyl)-6,7-dihydro-1H-cyclopenta[d]pyrimidin-2(5H)-one
  • 2-((1-(3-morpholinopropyl)-2-oxo-2,5,6,7-tetrahydro-1H-cyclopenta[d]pyrimidin-4-yl)thio)-N-(thiazol-2-yl)acetamide
The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.