Ethyl 2-hydroxyacetate

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Names

[ CAS No. ]:
623-50-7

[ Name ]:
Ethyl 2-hydroxyacetate

[Synonym ]:
ethyl 2-hydroxyacetate
Ethyl glycolate
ethyl hydroxyacetate
Acetic acid, 2-hydroxy-, ethyl ester
EINECS 210-798-4
MFCD00021970

Chemical & Physical Properties

[ Density]:
1.1±0.1 g/cm3

[ Boiling Point ]:
156.7±8.0 °C at 760 mmHg

[ Molecular Formula ]:
C4H8O3

[ Molecular Weight ]:
104.104

[ Flash Point ]:
61.7±0.0 °C

[ Exact Mass ]:
104.047340

[ PSA ]:
46.53000

[ LogP ]:
-0.54

[ Vapour Pressure ]:
1.0±0.6 mmHg at 25°C

[ Index of Refraction ]:
1.414

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
MC5410000
CHEMICAL NAME :
Glycolic acid, ethyl ester
CAS REGISTRY NUMBER :
623-50-7
BEILSTEIN REFERENCE NO. :
1743766
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C4-H8-O3
MOLECULAR WEIGHT :
104.12
WISWESSER LINE NOTATION :
Q1VO2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
Standard Draize test
ROUTE OF EXPOSURE :
Administration into the eye
SPECIES OBSERVED :
Rodent - guinea pig
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 11,150,1959 ** ACUTE TOXICITY DATA **
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1500 mg/kg
TOXIC EFFECTS :
Behavioral - general anesthetic Behavioral - muscle weakness Lungs, Thorax, or Respiration - cyanosis
REFERENCE :
JPPMAB Journal of Pharmacy and Pharmacology. (Pharmaceutical Soc. of Great Britain, 1 Lambeth High St., London SEI 7JN, UK) V.1- 1949- Volume(issue)/page/year: 11,150,1959

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26-S36/37/39-S37/39

[ RIDADR ]:
1993

[ WGK Germany ]:
3

[ RTECS ]:
MC5410000

[ Packaging Group ]:
III

[ Hazard Class ]:
3.2

[ HS Code ]:
2918199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • ethyl 2-bromoacetate
  • Glycolic acid
  • Ethanol
  • EDA
  • Betaine
  • Formaldehyde
  • ethyl chloroacetate
  • Diethyloxalate
  • 1,4-Dioxane-2,5-dione

DownStream

  • Ethyl 2-((5-bromo-3-nitropyridin-2-yl)oxy)acetate
  • ethyl 2-(cyanomethoxy)acetate
  • (1H-Benzoimidazol-2-yl)methanol
  • Benzyloxyacetic acid ethyl ester
  • (3-(4-CHLOROPHENYL)-1,2,4-OXADIAZOL-5-YL)METHANOL
  • 2-hydroxyacetohydrazide
  • 3-AMINO-FURO[2,3-B]PYRIDINE-2-CARBOXYLIC ACID ETHYL ESTER
  • ETHYL PROPIONYLACETATE
  • ETHOXYCARBONYLMETHYL PHENYLACETATE
  • Ethyl glyoxylate

Customs

[ HS Code ]: 2918199090

[ Summary ]:
2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles

Aldrichimica Acta 23 , 51, (1990)

Synthesis of ferrocenyl-substituted heterocycles: the beneficial effect of the microwave irradiation. Puciová M, et al.

Collect. Czech. Chem. Commun. 59(1) , 175-85, (1994)

Polycondensation of a-hydroxy acids by enzymes or PEG-modified enzymes in organic media. Ohya Y, et al.

J. Macromol. Sci., Part A: Pure Appl. Chem. 32(2) , 179-90, (1995)


More Articles

Related Compounds

  • ethyl 2-hydroxyacetate sodium salt
  • diethyl benzene-1,2-dicarboxylate,ethyl 2-hydroxyacetate
  • [2-(4-bromophenyl)-2-oxo-ethyl] 2-hydroxyacetate
  • ETHYL 2-(DIETHOXYPHOSPORYL)-2-HYDROXYACETATE
  • ethyl 2-azido-2-hydroxyacetate
  • ethyl 2-(3-chlorophenyl)-2-hydroxyacetate
  • N-[1-(2-methoxyethyl)-1H-indol-4-yl]-3-(3-methoxy-1,2-oxazol-5-yl)propanamide
  • (5-fluoro-1-methyl-1H-indol-2-yl)(2-phenylmorpholin-4-yl)methanone
  • N-(5-isopropyl-1,3,4-thiadiazol-2-yl)-3-(6-methoxy-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)propanamide
  • 2H-Pyran, 2-[(2,5-dimethyl-2,4-cyclopentadien-1-yl)methoxy]tetrahydro-
  • N-(1H-indol-6-yl)-4-([1,2,4]triazolo[4,3-a]pyridin-3-yl)butanamide
  • Methyl 2-{[(2,4-dimethyl-1,3-thiazol-5-yl)carbonyl]amino}-5-(2-methoxyphenyl)-1,3-thiazole-4-carboxylate
  • 3-(3-methoxy-1,2-oxazol-5-yl)-N-{4-[(1-methyl-1H-imidazol-2-yl)carbonyl]phenyl}propanamide
  • N-[2-(5-bromo-1H-indol-1-yl)ethyl]-2-chloro-5-(1H-1,2,3,4-tetraazol-1-yl)benzamide
  • N-(5-cyclopentyl-1,3,4-thiadiazol-2-yl)-2-(4-oxo-1,2,3-benzotriazin-3(4H)-yl)acetamide
  • 1-[4-(Methylsulfonyl)piperazin-1-yl]-3-(3-phenyl-1,2,4-oxadiazol-5-yl)propan-1-one
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