tert-Butyl O,O-dimethylphosphonoacetate

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Names

[ CAS No. ]:
62327-21-3

[ Name ]:
tert-Butyl O,O-dimethylphosphonoacetate

[Synonym ]:
MFCD00042939
tert-butyl 2-dimethoxyphosphorylacetate

Chemical & Physical Properties

[ Density]:
1.131

[ Boiling Point ]:
86-87ºC (0.02 mmHg)

[ Molecular Formula ]:
C₈H₁₇O₅P

[ Molecular Weight ]:
224.19100

[ Flash Point ]:
110ºC

[ Exact Mass ]:
224.08100

[ PSA ]:
71.64000

[ LogP ]:
1.81400

[ Index of Refraction ]:
1.434

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
Eyeshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
Xi:Irritant;

[ Risk Phrases ]:
R36/37/38

[ Safety Phrases ]:
S26

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Methyl 2-(dimethoxyphosphoryl)acetate
potassium t-butoxide

DownStream

tert-butyl 2-(bis((trimethylsilyl)oxy)phosphoryl)acetate
methyl iodide
3-cyclopentene-1-carboxylic acid, 1-(dimethoxyphosphinyl)-, 1,1-dimethylethyl ester
tert-butyl 3-pyridin-4-ylpropanoate
tert-butyl 2-(bromomethyl)acrylate

Articles

A novel synthesis of (+/-)-vermiculine.

J. Am. Chem. Soc. 99 , 646, (1977)

G.W.J. Fleet et al.

J. Chem. Soc. Perkin Trans. I , 905, (1984)

C. Kuroda et al.

J. Org. Chem. 51 , 956, (1986)

S-(tert-Butyl) O,O-diethyl dithiophosphate
2-dimethoxyphosphorylsulfanyl-2-methylpropane
tert-butyl o-tert-butylperbenzoate
tert-Butyl O-(tert-butyl)-D-threoninate hydrochloride
tert-butyl o-aminophenylsulfanyl acetate
N-(tert-butyl)-O-benzoylhydroxylamine
(3R)-3-[(2,2,2-trifluoroacetyl)amino]hexanoic acid
(2S)-2-(tert-butoxycarbonylamino)-3-[4-(trifluoromethyl)benzothiophen-3-yl]propanoic acid
benzyl N-(5-nitro-8-isoquinolyl)carbamate
3-[(1H-imidazol-5-yl)methyl]azetidin-3-ol
Methyl 4-ethynyl-2,6-dimethylbenzoate
4-(4-nitro-1H-pyrazol-3-yl)butan-1-amine
tert-butyl N-[2-(fluorosulfonyl)propyl]carbamate
2-acetamido-1H-imidazole-5-carboxylic acid
4-(5-Fluorofuran-2-yl)-1,3-oxazole
4-Methyl-5-(2-methylpropyl)pyridin-3-amine

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