rac 4-Hydroxydebrisoquine Hemisulfate

Suppliers

Names

[ Name ]:
rac 4-Hydroxydebrisoquine Hemisulfate

[Synonym ]:
( inverted exclamation markA)-3,4-Dihydro-4-hydroxy-2(1H)-isoquinolinecarboximidamide sulfate
( inverted exclamation markA)-4-Hydroxydebrisoquin sulfate
( inverted exclamation markA)-2-Amidino-4-hydroxy-1,2,3,4-tetrahydroisoquinoline sulfate

Chemical & Physical Properties

[ Melting Point ]:
262-265ºC

[ Molecular Formula ]:
C₁₀H₁₅N₃O₅S

[ Molecular Weight ]:
289.30800

[ Exact Mass ]:
289.07300

[ PSA ]:
156.32000

[ LogP ]:
1.59500

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H315-H319-H335

[ Precautionary Statements ]:
P261-P305 + P351 + P338

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Risk Phrases ]:
36/37/38

[ Safety Phrases ]:
26

[ RIDADR ]:
NONH for all modes of transport

Articles

Microsomal formation of nitric oxide and cyanamides from non-physiological N-hydroxyguanidines: N-hydroxydebrisoquine as a model substrate.

Biochem. Pharmacol. 58(3) , 439-45, (1999)

The microsomal oxidative transformation of a non-physiological N-hydroxyguanidine was demonstrated for the first time for N-hydroxydebrisoquine as a model substrate (Clement et al., Biochem Pharmacol ...

Halofantrine and chloroquine inhibit CYP2D6 activity in healthy Zambians.

Br. J. Clin. Pharmacol. 45(3) , 315-7, (1998)

To determine the effect of therapeutic loading doses of halofantrine and chloroquine on CYP2D6 activity in healthy black Zambians.Twenty healthy black male Zambians were phenotyped for CYP2D6 activity...

Determination of debrisoquine and 4-hydroxydebrisoquine by high-performance liquid chromatography: application to the evaluation of CYP2D6 genotype and debrisoquine metabolic ratio relationship.

Clin. Chem. Lab Med. 43(3) , 275-9, (2005)

The drug-metabolizing cytochrome P450 (CYP) enzyme CYP2D6 is involved in the metabolism of several clinically important drugs. So far more than 50 different CYP2D6 allelic variants have been described...

rac-4,5-Dihydro-5-(2-pyridyl)-3-isoxazolcarbonsaeure-ethylester
rac-4-ethyl-2-phenyloxazol-5(4H)-one
rac-4-benzyl-4-methyl-2-phenyl-1,3-oxazol-5(4H)-one
rac-4-methyldecan-2-one
(rac)-4-(1-cyclopropyl-ethoxy)-phenylamine
rac 4-Desmethoxy-4-nitro Omeprazole
3-Chloro-4-fluoro-5-(methylthio)benzoic acid
Methyl 3-chloro-2-fluoro-5-formylbenzoate
3-Bromo-5-isobutyl-2-methoxybenzaldehyde
Methyl 4-ethoxy-3-fluoro-2-(methylthio)benzoate
Ethyl 4-ethoxy-3-fluoro-2-(methylthio)benzoate
1-Bromo-3-fluoro-2-iodo-4-(methoxymethoxy)benzene
{[2-(Ethanesulfonyl)thiophen-3-yl]methyl}(propyl)amine
(3-Iodo-5-(trifluoromethoxy)phenyl)(methyl)sulfane
1-{1-[(Propan-2-yloxy)methyl]cyclopropyl}ethan-1-ol
2-(3-Bromo-2-fluorophenyl)ethane-1-sulfonyl fluoride

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