1,2-bis(2-methoxyphenyl)guanidine

Names

[ CAS No. ]:
6268-03-7

[ Name ]:
1,2-bis(2-methoxyphenyl)guanidine

[Synonym ]:
Di-o-anisylguanidine
N,N'-di-o-anisole guanidine

Chemical & Physical Properties

[ Density]:
1.15g/cm3

[ Boiling Point ]:
447.1ºC at 760 mmHg

[ Molecular Formula ]:
C15H17N3O2

[ Molecular Weight ]:
271.31400

[ Flash Point ]:
224.2ºC

[ Exact Mass ]:
271.13200

[ PSA ]:
66.37000

[ LogP ]:
3.40830

[ Index of Refraction ]:
1.57

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
ME8656000
CHEMICAL NAME :
Guanidine, N,N'-bis(2-methoxyphenyl)-
CAS REGISTRY NUMBER :
6268-03-7
BEILSTEIN REFERENCE NO. :
3387288
LAST UPDATED :
199612
DATA ITEMS CITED :
2
MOLECULAR FORMULA :
C15-H17-N3-O2
MOLECULAR WEIGHT :
271.35

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Endocrine - hyperglycemia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 41,127,1931
TYPE OF TEST :
LDLo - Lowest published lethal dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rabbit
DOSE/DURATION :
25 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Behavioral - excitement Endocrine - hyperglycemia
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 41,127,1931

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • iodoanisole
  • Guanidine nitrate
  • Cyanogen bromide
  • 2-Anisidine
  • methyl thiocyanate
  • Thiourea,N,N'-bis(2-methoxyphenyl)-
  • N,N'-bis-(2-methoxy-phenyl)-S-methyl-isothiourea
  • lead tetraacetate
  • Ammonia

DownStream

Related Compounds

  • 1,2-BIS[(2-METHOXYPHENYL)PHENYLPHOSPHINO]ETHANE
  • 1,2-bis(2-methoxyphenyl)ethan-1-ol
  • 1,2-bis(2-methoxyphenyl)ethan-1-ol
  • 1,2-bis(2-methoxyphenyl)-2-(triphenylphosphoranylidene)ethanone
  • 1,2-bis(2-methoxyphenyl)-2-pyrrolidin-1-yl-ethanol
  • 1,2-bis(2-methoxyphenyl)pentane-1,5-diol (en)1,5-Pentanediol, 1,2-bis(2-methoxyphenyl)- (en)
  • 1-{5-Methyl-[1,2,4]triazolo[1,5-a]pyrimidin-7-yl}-3-(pyrrolidine-1-carbonyl)pyrrolidine
  • 1-[(4-Chlorophenyl)methyl]-3-(pyrrolidine-1-carbonyl)pyrrolidine
  • 4-(1-{7-Methylthieno[3,2-d]pyrimidin-4-yl}piperidine-4-carbonyl)morpholine
  • 4-(4-methanesulfonyl-1,3-benzothiazol-2-yl)-N-methylmorpholine-2-carboxamide
  • Ethyl 4-chloropyrazolo[1,5-a]pyrazine-3-carboxylate
  • 4-{[1-(3-Fluoropyridin-2-yl)piperidin-4-yl]methoxy}pyridine-2-carboxamide
  • 3-(Pyrrolidine-1-carbonyl)-1-{thieno[2,3-d]pyrimidin-4-yl}pyrrolidine
  • 4-{[1-(5-Fluoropyridin-2-yl)piperidin-4-yl]methoxy}pyridine-2-carboxamide
  • 1-[(4-Fluorophenyl)methyl]-4-[3-(2-methoxyethyl)-1,2,4-thiadiazol-5-yl]piperazin-2-one
  • 2-Chloro-3-fluoro-5-iodo-6-methoxypyridin-4-amine
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