Isoquinoline,3,4-dihydro-6,7-dimethoxy-1-methyl-, hydrochloride (1:1)

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Names

[ CAS No. ]:
6268-86-6

[ Name ]:
Isoquinoline,3,4-dihydro-6,7-dimethoxy-1-methyl-, hydrochloride (1:1)

[Synonym ]:
6,7-dimethoxy-1-methyl-3,4-dihydroisoquinoline hydrochloride
1-methyl-6,7-dimethoxy-3,4-dihydroisoquinoline hydrochloride
3,4-dihydro-6,7-dimethoxy-1-methylisoquinoline hydrochloride
dimethoxy-6,7 methyl-1 dihydro-3,4 isoquinoleine chlorhydrate
6,7-Dimethoxy-1-methyl-3,4-dihydro-isochinolin,Hydrochlorid

Chemical & Physical Properties

[ Boiling Point ]:
312.1ºC at 760 mmHg

[ Molecular Formula ]:
C12H16ClNO2

[ Molecular Weight ]:
241.71400

[ Flash Point ]:
117ºC

[ Exact Mass ]:
241.08700

[ PSA ]:
30.82000

[ LogP ]:
2.30650

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
NW7628860
CHEMICAL NAME :
Isoquinoline, 3,4-dihydro-6,7-dimethoxy-1-methyl-, hydrochloride
CAS REGISTRY NUMBER :
6268-86-6
LAST UPDATED :
198806
DATA ITEMS CITED :
1
MOLECULAR FORMULA :
C12-H15-N-O2.Cl-H
MOLECULAR WEIGHT :
241.74

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
108 mg/kg
TOXIC EFFECTS :
Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea
REFERENCE :
JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 76,263,1942

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Acetamide, N-(3,4-dimethoxyphenethyl)- (8CI)
  • phosphoryl trichloride
  • 3,4-Dimethoxyphenethylamine

DownStream

  • 6,7-Dimethoxy-1-methyl-3,4-dihydroisoquinoline

Related Compounds

  • 2-[(2,2-Dimethylpropyl)[2-(furan-2-yl)-2-hydroxypropyl]amino]ethane-1-sulfonyl fluoride
  • 2-[(Cyclopropylmethyl)(2-oxo-2,3-dihydro-1,3-benzoxazol-7-yl)amino]ethane-1-sulfonyl fluoride
  • 2-chloro-N-[(3S)-2-hydroxy-2,4-dimethylpentan-3-yl]-N-{[1-(propan-2-yl)-1H-pyrazol-5-yl]methyl}acetamide
  • 2-chloro-N-(2,3-dihydro-1H-inden-2-yl)-N-[(2,4-dimethylpyrimidin-5-yl)methyl]acetamide
  • N-(2,2-dimethylpropyl)-N-[2-(furan-2-yl)-2-hydroxypropyl]prop-2-enamide
  • N-[(2-tert-butylpyrimidin-5-yl)methyl]-N-[(5-methylthiophen-2-yl)methyl]prop-2-enamide
  • 3-[2-(1-methyl-1H-pyrazol-5-yl)piperidine-1-carbonyl]benzene-1-sulfonyl fluoride
  • Tert-butyl9,9-difluoro-4-oxo-1-azaspiro[5.5]undecane-1-carboxylate
  • N-[3-(cyclopropylmethyl)-2-oxo-2,3-dihydro-1,3-benzoxazol-6-yl]prop-2-enamide
  • N-[(2,4-difluorophenyl)methyl]-1-(prop-2-enoyl)-N-propylpiperidine-4-carboxamide
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