Ethoxyacetic acid

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Names

[ CAS No. ]:
627-03-2

[ Name ]:
Ethoxyacetic acid

[Synonym ]:
EINECS 210-978-2
2-ethoxyacetic acid
MFCD00004310

Chemical & Physical Properties

[ Density]:
1.102 g/mL at 25 °C(lit.)

[ Boiling Point ]:
97-100 °C11 mm Hg(lit.)

[ Molecular Formula ]:
C4H8O3

[ Molecular Weight ]:
104.10500

[ Flash Point ]:
208 °F

[ Exact Mass ]:
104.04700

[ PSA ]:
46.53000

[ LogP ]:
0.10750

[ Index of Refraction ]:
n20/D 1.419(lit.)

[ Stability ]:
Stable. Combustible. Incompatible with strong oxidizing agents.

[ Water Solubility ]:
soluble

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
AH3600000
CHEMICAL NAME :
Acetic acid, ethoxy-
CAS REGISTRY NUMBER :
627-03-2
BEILSTEIN REFERENCE NO. :
1743037
LAST UPDATED :
199710
DATA ITEMS CITED :
4
MOLECULAR FORMULA :
C4-H8-O3
MOLECULAR WEIGHT :
104.12

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
DOSE :
6352 mg/kg
SEX/DURATION :
male 11 day(s) pre-mating
TOXIC EFFECTS :
Reproductive - Paternal Effects - testes, epididymis, sperm duct
REFERENCE :
TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 69,385,1983 *** REVIEWS *** TOXICOLOGY REVIEW FAATDF Fundamental and Applied Toxicology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1981- Volume(issue)/page/year: 13,747,1989

Safety Information

[ Symbol ]:

GHS05

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H314

[ Precautionary Statements ]:
P280-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
C:Corrosive;

[ Risk Phrases ]:
R34

[ Safety Phrases ]:
S26-S36/37/39-S45

[ RIDADR ]:
UN 3265 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
AH3600000

[ Packaging Group ]:
III

[ Hazard Class ]:
8

[ HS Code ]:
2918990090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Ethanol
  • Chloroacetic acid
  • Bromoacetic acid
  • 2-ethoxyacetamide
  • 2-Ethoxyethanol
  • Carbon dioxide
  • magnesium,methanidyloxyethane,chloride
  • carbon monoxide
  • Triethyl orthoformate
  • Ethoxychloromethane

DownStream

  • Formaldehyde
  • diethoxymethane
  • Ethanol
  • Ethyl 2-ethoxyacetate
  • Glycolic acid
  • 1-imidazol-1-yl-2-methoxyethanone
  • Ethyl iodide
  • ethoxyacetyl chloride
  • methyl 2-ethoxyacetate
  • tributylstannyl 2-ethoxyacetate

Customs

[ HS Code ]: 2918990090

[ Summary ]:
2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

Decrease of intracellular pH as possible mechanism of embryotoxicity of glycol ether alkoxyacetic acid metabolites.

Toxicol. Appl. Pharmacol. 245(2) , 236-43, (2010)

Embryotoxicity of glycol ethers is caused by their alkoxyacetic acid metabolites, but the mechanism underlying the embryotoxicity of these acid metabolites is so far not known. The present study inves...

Chemical class-specific gene expression changes in the zebrafish embryo after exposure to glycol ether alkoxy acids and 1,2,4-triazole antifungals.

Reprod. Toxicol. 32(2) , 245-52, (2011)

The zebrafish embryotoxicity test (ZET) is an alternative test to predict embryotoxicity of substances based on morphological assessment. Implementing transcriptomics may increase sensitivity and obje...

Mutagenicity of ethylene glycol ethers and of their metabolites in Salmonella typhimurium his-.

Mutat. Res. 341(4) , 281-7, (1995)

Ethylene glycol ethers, their aldehyde and their acid metabolites were evaluated for their mutagenicity with the Ames test. The Salmonella typhimurium his- tester strains TA 97a, TA 98, TA 100 and TA ...


More Articles

Related Compounds

  • Ethoxyacetic acid ethyl ester
  • ethoxyacetic acid ethyl ester
  • Dicyclohexylethoxyacetic acid
  • (2-aminoethoxy)ethoxyacetic acid
  • 2-(2-azidoethoxy)ethoxyacetic acid
  • 2-(4-fluorophenyl)ethoxyacetic acid
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-{[6-(4-Fluorophenyl)-2H,3H-imidazo[2,1-B][1,3]thiazol-5-YL]methyl}-2,3-dimethylbenzamide
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide