3-Chloro-1-propanol
Suppliers
Names
[ CAS No. ]:
627-30-5
[ Name ]:
3-Chloro-1-propanol
[Synonym ]:
1-Propanol, 3-chloro-
3-chloro-1-hydroxy-propane
1-hydroxy-3-chloropropane
1-chloro-3-hydroxypropane
3-hydroxypropyl chloride
trimethylene chlorohydrin
MFCD00002943
1-Chloro-3-hydroxypropane, 3-Chloro-1-propanol, Trimethylene chlorohydrin
3-Chloro-1-propanol
3-Chloropropan-1-ol
3-chloropropyl alcohol
EINECS 210-992-9
Chemical & Physical Properties
[ Density]:
1.1±0.1 g/cm3
[ Boiling Point ]:
165.0±0.0 °C at 760 mmHg
[ Melting Point ]:
-20 °C
[ Molecular Formula ]:
C3H7ClO
[ Molecular Weight ]:
94.540
[ Flash Point ]:
73.3±0.0 °C
[ Exact Mass ]:
94.018539
[ PSA ]:
20.23000
[ LogP ]:
0.50
[ Vapour Pressure ]:
0.6±0.6 mmHg at 25°C
[ Index of Refraction ]:
1.427
[ Stability ]:
Stability Stable, but light-sensitive. Combustible. Incompatible with strong oxidizing agents.
[ Water Solubility ]:
300 g/L (20 ºC)
MSDS
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- UA8930000
- CHEMICAL NAME :
- 1-Propanol, 3-chloro-
- CAS REGISTRY NUMBER :
- 627-30-5
- BEILSTEIN REFERENCE NO. :
- 0773655
- LAST UPDATED :
- 199710
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C3-H7-Cl-O
- MOLECULAR WEIGHT :
- 94.55
- WISWESSER LINE NOTATION :
- Q3G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2300 mg/kg
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity Gastrointestinal - ulceration or bleeding from stomach Liver - other changes
MUTATION DATA
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 33 ug/plate
- REFERENCE :
- ENMUDM Environmental Mutagenesis. (New York, NY) V.1-9, 1979-87. For publisher information, see EMMUEG. Volume(issue)/page/year: 9(Suppl 9),1,1987
Safety Information
[ Symbol ]:
GHS07
[ Signal Word ]:
Warning
[ Hazard Statements ]:
H315-H319-H335
[ Precautionary Statements ]:
P261-P305 + P351 + P338
[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter
[ Hazard Codes ]:
Xn:Harmful;
[ Risk Phrases ]:
R22;R36/37/38
[ Safety Phrases ]:
S26-S36-S36/37/39
[ RIDADR ]:
UN 2849 6.1/PG 3
[ WGK Germany ]:
3
[ RTECS ]:
UA8930000
[ Packaging Group ]:
III
[ Hazard Class ]:
6.1
[ HS Code ]:
29055910
Synthetic Route
Precursor & DownStream
Precursor
DownStream
Customs
[ HS Code ]: 2905590090
[ Summary ]:
2905590090 other halogenated, sulphonated, nitrated or nitrosated derivatives of acyclic alcohols。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0%
Articles
J. Reprod. Fertil. 111(2) , 285-90, (1997)
When incubated in the absence of exogenous substrates, washed boar spermatozoa maintained a high energy charge potential (ECP) for at least 5 h. Addition of 3-chloro-1-hydroxypropanone, an inhibitor o...
Int. J. Androl. 23(4) , 243-7, (2000)
3-(36)Chloro-1-hydroxypropanone (CHOP), a specific inhibitor of sperm glycolysis in vitro, is rapidly metabolized by the male rat to alpha-chlorohydrin, 3-chlorolactate and the inhibitory sperm metabo...
Reprod. Fertil. Dev. 9(6) , 577-81, (1997)
Boar sperm rapidly interconverted dihydroxyacetone phosphate and glyceraldehyde 3-phosphate, produced fructose-1,6-bisphosphate, approximately equilibrium concentrations of fructose 6-phosphate and gl...