N-Ethylformamide

Suppliers

Names

[ CAS No. ]:
627-45-2

[ Name ]:
N-Ethylformamide

[Synonym ]:
EINECS 211-001-2
N-formylethylamine
monoethyl-formamide
Ethylformamide
MFCD00042672
N-ethyl carboxamide
N-ethyl-formamide
Formamide,N-ethyl
N-Aethylformamid [German]

Chemical & Physical Properties

[ Density]:
0.950 g/mL at 20ºC(lit.)

[ Boiling Point ]:
202-204ºC

[ Melting Point ]:
-60.43°C (estimate)

[ Molecular Formula ]:
C3H7NO

[ Molecular Weight ]:
73.09380

[ Flash Point ]:
67ºC

[ Exact Mass ]:
73.05280

[ PSA ]:
29.10000

[ LogP ]:
0.77910

[ Index of Refraction ]:
n20/D 1.432

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
LQ2725000
CHEMICAL NAME :
Formamide, N-ethyl-
CAS REGISTRY NUMBER :
627-45-2
BEILSTEIN REFERENCE NO. :
1737860
LAST UPDATED :
199701
DATA ITEMS CITED :
3
MOLECULAR FORMULA :
C3-H7-N-O
MOLECULAR WEIGHT :
73.11
WISWESSER LINE NOTATION :
VHM2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Unreported
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
3 gm/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 18,645,1968
TYPE OF TEST :
LD - Lethal dose
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
>1200 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
THERAP Therapie. (Doin, Editeurs, 8, Place de l'Odeon, F-75006 Paris, France) V.1- 1946- Volume(issue)/page/year: 27,873,1972

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves

[ Hazard Codes ]:
Xi

[ Safety Phrases ]:
S23-S24/25

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ RTECS ]:
LQ2725000

[ HS Code ]:
2924199090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • Formic Acid
  • Ethylamine
  • Ethyl formate
  • (Z)-Methanimidic acid
  • Acetonitrile
  • N-Vinylformamide
  • methyl formate
  • Ethyl isocyanide
  • Ethyl isocyanate
  • formyl fluoride

DownStream

  • 2-(Ethylamino)benzoxazole
  • Acetonitrile
  • propionitrile
  • N-Cyclohexyl-N-ethylcyclohexanamine
  • 2,6-Dihydroxypurine
  • N-Ethylcyclohexylamine
  • N'-ethyl-N,N-dimethylmethanimidamide
  • N,N-Dimethylformamide
  • tert-Butanol
  • 1,3-Diethylurea

Customs

[ HS Code ]: 2924199090

[ Summary ]:
2924199090. other acyclic amides (including acyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles

N-methylformamide: antitumour activity and metabolism in mice.

Br. J. Cancer 45(6) , 843-50, (1982)

The antitumour activities of N-methylformamide, N-ethylformamide and formamide against a number of murine tumours in vivo (Sarcoma 180, M5076 ovarian sarcoma and TLX5 lymphoma) have been estimated. In...

Cloning and expression of rat CYP2E1 in Saccharomyces cerevisiae: detection of genotoxicity of N-alkylformamides.

Environ. Mol. Mutagen. 36(2) , 97-104, (2000)

A cDNA coding for rat cytochrome P450 2E1 was cloned into the multicopy vector pYeDP60 and expressed in haploid RSY6 and diploid RS112 yeast strains of Saccharomyces cerevisiae under control of the GA...

An investigation of the relationship between the hepatotoxicity and the metabolism of N-alkylformamides.

J. Pharmacol. Exp. Ther. 240(1) , 265-70, (1987)

The hepatotoxicity and metabolism of the following close analogs of the hepatotoxic antitumor agent N-methylformamide (NMF) were investigated in CBA/CA mice: N-ethylformamide (NEF), dimethylformamide ...


More Articles

Related Compounds

  • N-amino-N-ethylformamide
  • N-Allyl-N-ethylformamide
  • N-Butyl-N-ethylformamide
  • N-methyl-N-ethylformamide
  • N-benzyl-N-ethylformamide
  • N-cyclohexyl-N-ethylformamide
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine