APM

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Names

[ CAS No. ]:
627-76-9

[ Name ]:
APM

[Synonym ]:
2-Aminopimelate
Heptanedioic acid, 2-amino-, (±)-
UNII:V76629V970
DL-2-Aminopimelate
DL-2-Aminopimelic Acid
Heptanedioic acid, 2-amino-
2-Aminoheptanedioic acid
dl-α-Aminopimelic acid
EINECS 211-011-7
(±)-2-Aminopimelic acid
APM
MFCD00053314

Chemical & Physical Properties

[ Density]:
1.3±0.1 g/cm3

[ Boiling Point ]:
378.5±37.0 °C at 760 mmHg

[ Melting Point ]:
223 °C (dec.)(lit.)

[ Molecular Formula ]:
C₇H₁₃NO₄

[ Molecular Weight ]:
175.182

[ Flash Point ]:
182.7±26.5 °C

[ Exact Mass ]:
175.084457

[ PSA ]:
100.62000

[ LogP ]:
-0.66

[ Vapour Pressure ]:
0.0±1.8 mmHg at 25°C

[ Index of Refraction ]:
1.510

[ Storage condition ]:
Store at RT.

MSDS

Click to get detail MSDS

Safety Information

[ Personal Protective Equipment ]:
Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter

[ RIDADR ]:
NONH for all modes of transport

[ WGK Germany ]:
3

[ HS Code ]:
2922499990

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-KETOPIMELIC ACID
Ethyl 2-oxocyclohexanecarboxylate
7,7-dichloro-hept-6-enoic acid
DL-Norleucine, 6-hydroxy-
(D,L)-Cbz-ε-hydroxynorleucine
1,4-Dibromobutane
Ethyl phthalimidomalonate
1-acetylamino-5-cyano-pentane-1,1,5-tricarboxylic acid triethyl ester

DownStream

Customs

[ HS Code ]: 2922499990

[ Summary ]:
HS:2922499990 other amino-acids, other than those containing more than one kind of oxygen function, and their esters; salts thereof VAT:17.0% Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) MFN tariff:6.5% General tariff:30.0%

Articles

Peptides containing 2-aminopimelic acid. Synthesis and study of in vitro effects on bacterial cells.

Int. J. Pept. Protein Res. 37 , 103-111, (1991)

Taking advantage of the peptide transport strategy, we have designed and synthesized several new peptides containing 2-aminopimelic acid (Apm), an inhibitor of the diaminopimelate pathway in bacteria:...

Peptides of 2-aminopimelic acid: antibacterial agents that inhibit diaminopimelic acid biosynthesis.

J. Med. Chem. 29 , 89-95, (1986)

Succinyl-CoA:tetrahydrodipicolinate-N-succinyltransferase is a key enzyme in the biosynthesis of diaminopimelic acid (DAP), a component of the cell wall peptidoglycan of nearly all bacteria. This enzy...

N-methylnicotinamide and nicotinamide N-methyltransferase are associated with microRNA-1291-altered pancreatic carcinoma cell metabolome and suppressed tumorigenesis.

Carcinogenesis 35(10) , 2264-72, (2014)

Platinum resistance is the most crucial problem for treatment of ovarian cancer. There is a clinical need for new treatment strategies which overcome platinum resistance. Recently high level of AKT wa...

APM
BAPTA-APM
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tert-butyl N-{[2-(2-methylpropyl)piperidin-4-yl]methyl}carbamate
3-[[4-[2-(4-Methylphenyl)ethyl]phenyl]sulfonyl]propanoic acid
N-{[2-bromo-5-(cyclopentyloxy)phenyl]methyl}cyclopropanamine
N-[[[3-(4-fluoro-1-piperidinyl)-2-pyridinyl]amino]thioxomethyl]carbamic acid ethyl ester
Methyl 4-(trifluoromethylsulfonyloxymethyl)bicyclo[2.2.2]octane-1-carboxylate
2-(4,5-Difluoro-2-methoxyphenyl)ethane-1-sulfonyl chloride
5-(4-Methoxy-3,5-dimethylphenyl)thiazol-2-amine
2-[1-(2-Bromo-5-hydroxyphenyl)cyclopropyl]acetic acid
2-(4-(3-Methoxyphenyl)-1H-pyrazol-1-yl)ethanamine
2-[1-(3-Bromo-2-hydroxyphenyl)cyclopropyl]acetic acid

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APM