SD-208

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Names

[ CAS No. ]:
627536-09-8

[ Name ]:
SD-208

[Synonym ]:
ALK5 Inhibitor V
2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
2-(5-Chloro-2-fluorophenyl)-N-(4-pyridinyl)-4-pteridinamine
SD-208
4-Pteridinamine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
SD208

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
460.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C17H10ClFN6

[ Molecular Weight ]:
352.753

[ Flash Point ]:
232.2±28.7 °C

[ Exact Mass ]:
352.063965

[ PSA ]:
76.48000

[ LogP ]:
2.69

[ Appearance of Characters ]:
off-white to tan

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.717

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: >5mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

Articles

Inhibition of Transforming Growth Factor-β (TGF-β) Signaling by Scutellaria baicalensis and Fritillaria cirrhosa Extracts in Endometrial Cancer.

J. Cell. Biochem. 116 , 1797-805, (2015)

Transforming growth factor-β (TGF-β), regulates cell proliferation, angiogenesis, metastasis, and is an inducer of epithelial-mesenchymal transition (EMT). Cancer cells exhibit activated TGF-β/SMAD si...

Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?

Invest. Ophthalmol. Vis. Sci. 51(4) , 1857-65, (2010)

Purpose. An early hallmark of preclinical diabetic retinopathy is thickening of the capillary basal lamina (BL). TGF-beta, a multipotent cytokine acting through its receptors ALK5 and -1, has been pos...

SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo.

Cancer Res. 64 , 7954-7961 , (2004)

The cytokine transforming growth factor (TGF)-beta, by virtue of its immunosuppressive and promigratory properties, has become a major target for the experimental treatment of human malignant gliomas....


More Articles

Related Compounds

  • SD-57881
  • SD-1029
  • SD 1008
  • SD 2218
  • sd alcohol 1
  • sd alcohol 40
  • dendronesterol B
  • 2',2'-Difluoro-2'-deoxy-3'-O,N-bis(tert-butyloxycarbonyl)cytidine
  • (2,2-Diethyl-1,3-dioxan-5-yl)methanol
  • 1h-Isoindol-1-one,3-ethoxy-2,3-dihydro-2-phenyl-3-(phenylmethyl)-
  • 8-[(Trifluoromethylsulfonyl)oxy]-1,4-dioxaspiro[4.5]deca-7-ene-7-carboxylic acid methyl ester
  • N-(2-benzoyl-4-nitrophenyl)-[1,1'-biphenyl]-4-carboxamide
  • Methyl 3,5-dimethyl-4-isoxazolebutanoate
  • 5-Amino-2-chlorobenzoic acid 1-allyloxycarbonyl-1-methyl-ethyl ester
  • (3,4-Dichlorophenyl)methanesulfonic acid
  • Methyl 3-(furan-2-yl)-2-methyl-3-oxopropanoate
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