SD-208

Suppliers

Names

[ Name ]:
SD-208

[Synonym ]:
ALK5 Inhibitor V
2-(5-chloro-2-fluorophenyl)-N-(pyridin-4-yl)pteridin-4-amine
2-(5-Chloro-2-fluorophenyl)-N-(4-pyridinyl)-4-pteridinamine
SD-208
4-Pteridinamine, 2-(5-chloro-2-fluorophenyl)-N-4-pyridinyl-
SD208

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
460.4±45.0 °C at 760 mmHg

[ Molecular Formula ]:
C₁₇H₁₀ClFN₆

[ Molecular Weight ]:
352.753

[ Flash Point ]:
232.2±28.7 °C

[ Exact Mass ]:
352.063965

[ PSA ]:
76.48000

[ LogP ]:
2.69

[ Appearance of Characters ]:
off-white to tan

[ Vapour Pressure ]:
0.0±1.1 mmHg at 25°C

[ Index of Refraction ]:
1.717

[ Storage condition ]:
2-8°C

[ Water Solubility ]:
DMSO: >5mg/mL

MSDS

Click to get detail MSDS

Safety Information

[ Symbol ]:

GHS07

[ Signal Word ]:
Warning

[ Hazard Statements ]:
H302

[ Personal Protective Equipment ]:
dust mask type N95 (US);Eyeshields;Gloves

[ Hazard Codes ]:
Xn

[ Risk Phrases ]:
22

[ RIDADR ]:
NONH for all modes of transport

Articles

Inhibition of Transforming Growth Factor-β (TGF-β) Signaling by Scutellaria baicalensis and Fritillaria cirrhosa Extracts in Endometrial Cancer.

J. Cell. Biochem. 116 , 1797-805, (2015)

Transforming growth factor-β (TGF-β), regulates cell proliferation, angiogenesis, metastasis, and is an inducer of epithelial-mesenchymal transition (EMT). Cancer cells exhibit activated TGF-β/SMAD si...

Differential TGF-{beta} signaling in retinal vascular cells: a role in diabetic retinopathy?

Invest. Ophthalmol. Vis. Sci. 51(4) , 1857-65, (2010)

Purpose. An early hallmark of preclinical diabetic retinopathy is thickening of the capillary basal lamina (BL). TGF-beta, a multipotent cytokine acting through its receptors ALK5 and -1, has been pos...

SD-208, a novel transforming growth factor beta receptor I kinase inhibitor, inhibits growth and invasiveness and enhances immunogenicity of murine and human glioma cells in vitro and in vivo.

Cancer Res. 64 , 7954-7961 , (2004)

The cytokine transforming growth factor (TGF)-beta, by virtue of its immunosuppressive and promigratory properties, has become a major target for the experimental treatment of human malignant gliomas....

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2-(3-Bromoprop-1-en-2-yl)-5-(trifluoromethyl)pyridine
(1S)-2,2,2-trifluoro-1-[2-methoxy-3-(trifluoromethyl)phenyl]ethan-1-ol
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1-(3-Chloroprop-1-en-2-yl)-2-methoxy-3-(trifluoromethyl)benzene
3-[2-Methoxy-3-(trifluoromethyl)phenyl]-2,2-dimethylcyclopropane-1-carboxylic acid
1-[3,5-Bis(trifluoromethyl)phenyl]-2-fluoroethan-1-ol

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