N-N-Propylformamide

Suppliers

Names

[ Name ]:
N-N-Propylformamide

[Synonym ]:
Formamide,N-propyl
N-propyl carboxamide
N-N-Propylformamide
N-Propyl-formamide
N-Propyl-formamid
FORMAMIDE,N-n-PROPYL
Ameisensaeure-propylamid

Chemical & Physical Properties

[ Density]:
0.865g/cm3

[ Boiling Point ]:
197.2ºC at 760 mmHg

[ Molecular Formula ]:
C₄H₉NO

[ Molecular Weight ]:
87.12040

[ Flash Point ]:
96.8ºC

[ Exact Mass ]:
87.06840

[ PSA ]:
29.10000

[ LogP ]:
1.16920

[ Index of Refraction ]:
1.399

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ3325000

CHEMICAL NAME :: Formamide, N-n-propyl-

CAS REGISTRY NUMBER :: 6281-94-3

BEILSTEIN REFERENCE NO. :: 1739276

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C4-H9-N-O

MOLECULAR WEIGHT :: 87.14

WISWESSER LINE NOTATION :: VHM3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 26,596,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 26,596,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg/36D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 26,596,1973

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Propylamine
Formic Acid
Sodium ethoxide
Carbon dioxide
Trimethyl orthoformate
(Z)-Methanimidic acid
propionitrile
Ethyl formate
Ethyl chloroformate

DownStream

Propylamine
Methyl-n-propylamine
N2-n-propyl-N1,N1-dimethylformamidine
N,N-Dimethylformamide
tert-Butanol
propyl isocyanide

Related Compounds

N-methyl-N-propylformamide
N-n-propyl-N-formylhydrazine
(N,N-bis(2-hydroxyethyl)dithiocarbamato-S,S')dichlorogold(III)
N,N-Dipropyldodecanamide
N,N-dibenzyl-1-phenyl-ethane-1,2-diamine
N,N-Bis(2-methylpropyl)benzenamine
4-(6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl)-N-(4-phenoxyphenyl)butanamide
N-[4-(diethylamino)-2-methylphenyl]-4-[6-oxo-3-(thiophen-2-yl)-1,6-dihydropyridazin-1-yl]butanamide
N-(2,5-difluorophenyl)-4-[6-oxo-3-(thiophen-2-yl)-1,6-dihydropyridazin-1-yl]butanamide
2-[4-(6-Methyl-1,2,3,4-tetrahydroquinolin-1-yl)-4-oxobutyl]-6-(thiophen-2-yl)-2,3-dihydropyridazin-3-one
N-[2-methoxy-5-(trifluoromethyl)phenyl]-4-[6-oxo-3-(thiophen-2-yl)-1,6-dihydropyridazin-1-yl]butanamide
1-(Bromomethyl)-1H-pyrrole-2,5-dione
N-(5-acetamido-2-methoxyphenyl)-4-(6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl)butanamide
4-[6-oxo-3-(thiophen-2-yl)-1,6-dihydropyridazin-1-yl]-N-(4-sulfamoylphenyl)butanamide
4-(6-oxo-3-(thiophen-2-yl)pyridazin-1(6H)-yl)-N-(4-sulfamoylphenethyl)butanamide
3-(4-chlorobenzenesulfonyl)-N-[5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,3,4-oxadiazol-2-yl]propanamide

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