N-N-Propylformamide

Suppliers

Names

[ Name ]:
N-N-Propylformamide

[Synonym ]:
Formamide,N-propyl
N-propyl carboxamide
N-N-Propylformamide
N-Propyl-formamide
N-Propyl-formamid
FORMAMIDE,N-n-PROPYL
Ameisensaeure-propylamid

Chemical & Physical Properties

[ Density]:
0.865g/cm3

[ Boiling Point ]:
197.2ºC at 760 mmHg

[ Molecular Formula ]:
C₄H₉NO

[ Molecular Weight ]:
87.12040

[ Flash Point ]:
96.8ºC

[ Exact Mass ]:
87.06840

[ PSA ]:
29.10000

[ LogP ]:
1.16920

[ Index of Refraction ]:
1.399

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: LQ3325000

CHEMICAL NAME :: Formamide, N-n-propyl-

CAS REGISTRY NUMBER :: 6281-94-3

BEILSTEIN REFERENCE NO. :: 1739276

LAST UPDATED :: 199612

DATA ITEMS CITED :: 3

MOLECULAR FORMULA :: C4-H9-N-O

MOLECULAR WEIGHT :: 87.14

WISWESSER LINE NOTATION :: VHM3

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 440 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 26,596,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 380 mg/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - somnolence (general depressed activity)

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 26,596,1973 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 180 mg/kg/36D-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - other changes in urine composition Blood - changes in serum composition (e.g. TP, bilirubin, cholesterol) Biochemical - Metabolism (Intermediary) - Plasma proteins not involving coagulation

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 26,596,1973

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

Propylamine
Formic Acid
Sodium ethoxide
Carbon dioxide
Trimethyl orthoformate
(Z)-Methanimidic acid
propionitrile
Ethyl formate
Ethyl chloroformate

DownStream

Propylamine
Methyl-n-propylamine
N2-n-propyl-N1,N1-dimethylformamidine
N,N-Dimethylformamide
tert-Butanol
propyl isocyanide

Related Compounds

N-methyl-N-propylformamide
N-n-propyl-N-formylhydrazine
(N,N-bis(2-hydroxyethyl)dithiocarbamato-S,S')dichlorogold(III)
N,N-Dipropyldodecanamide
N,N-dibenzyl-1-phenyl-ethane-1,2-diamine
N,N-Bis(2-methylpropyl)benzenamine
3-(5-Bromo-2-hydroxyphenyl)-2,2-dimethylcyclopropane-1-carboxylic acid
2-[1-(3-Ethyloxetan-3-yl)cyclobutyl]ethan-1-amine
Methyl 2-amino-3-(4-ethylphenyl)-3-methylbutanoate
rac-methyl 5-[(1R,2R)-2-aminocyclopropyl]-1-methyl-1H-pyrazole-4-carboxylate
2-[3-(Methoxymethyl)phenyl]prop-2-enoic acid
5-(4-benzylmorpholin-2-yl)-1H-imidazol-2-amine
1-(6-Methoxy-1,3-dioxaindan-5-yl)-3-oxocyclobutane-1-carbonitrile
2,2-Dimethyl-3-[2-(methylamino)acetyl]-1lambda6-thiolane-1,1-dione
3-Hydroxy-3-(2-methyl-5-nitrophenyl)propanoic acid
1-[1-methyl-3-(oxan-4-yl)-1H-pyrazol-4-yl]-2-(methylamino)ethan-1-one

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