2-Chloro-5-nitroaniline

Names

[ CAS No. ]:
6283-25-6

[ Name ]:
2-Chloro-5-nitroaniline

[Synonym ]:
MFCD00007668
2-Chloro-5-nitroaniline
Benzenamine, 2-chloro-5-nitro-
EINECS 228-498-7

Chemical & Physical Properties

[ Density]:
1.5±0.1 g/cm3

[ Boiling Point ]:
314.6±22.0 °C at 760 mmHg

[ Melting Point ]:
118-120 °C(lit.)

[ Molecular Formula ]:
C₆H₅ClN₂O₂

[ Molecular Weight ]:
172.569

[ Flash Point ]:
144.1±22.3 °C

[ Exact Mass ]:
172.003952

[ PSA ]:
71.84000

[ LogP ]:
2.40

[ Vapour Pressure ]:
0.0±0.7 mmHg at 25°C

[ Index of Refraction ]:
1.646

MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BX1500000

CHEMICAL NAME :: Aniline, 2-chloro-5-nitro-

CAS REGISTRY NUMBER :: 6283-25-6

BEILSTEIN REFERENCE NO. :: 2208878

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C6-H5-Cl-N2-O2

MOLECULAR WEIGHT :: 172.58

WISWESSER LINE NOTATION :: ZR BG ENW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2015 mg/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - muscle weakness

REFERENCE :: TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 206512

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 400 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 206512

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1600 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 206512

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 800 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: TSCAT* Office of Toxic Substances Report. (U.S. Environmental Protection Agency, Office of Toxic Substances, 401 M St., SW, Washington, DC 20460) Volume(issue)/page/year: OTS 206512

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 180 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: CSLNX* U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. (Aberdeen Proving Ground, MD 21010) Volume(issue)/page/year: NX#03227 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 12660 mg/kg/15D-C

TOXIC EFFECTS :: Liver - changes in liver weight Endocrine - changes in spleen weight Blood - other changes

REFERENCE :: NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0570907

Safety Information

[ Symbol ]:

GHS06, GHS08, GHS09

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H300-H310-H330-H373-H411

[ Precautionary Statements ]:
P260-P264-P273-P280-P284-P301 + P310

[ Personal Protective Equipment ]:
Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges

[ Hazard Codes ]:
T+:Verytoxic;N:Dangerous for the environment;

[ Risk Phrases ]:
R26/27/28;R33;R51/53

[ Safety Phrases ]:
S28-S36/37-S45-S61-S28A

[ RIDADR ]:
UN 2237 6.1/PG 3

[ WGK Germany ]:
3

[ RTECS ]:
BX1500000

[ Packaging Group ]:
III

[ Hazard Class ]:
6.1

[ HS Code ]:
2921420090

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

2-Bromo-5-nitroaniline
2,4-Dinitrochlorobenzene
2-Chloroaniline
2-nitro-4-amino-5-chlorobenzoic acid
Benzamide,2-chloro-5-nitro-
1H-Isoindole-1,3(2H)-dione,2-(2-chlorophenyl)-
2-Chloro-5-nitrobenzonitrile
2'-Chloroacetanilide
nitric acid
Sulfuric acid

DownStream

2-Chloro-N-(2-chloro-5-nitrophenyl)acetamide
N-(2-chloro-5-nitrophenyl)-2-(4-oxoquinazolin-3-yl)acetamide
1H-Benzimidazole,1-methyl-5-nitro-
2-Chloro-5-nitro-benzenesulfonyl chloride
N1-Methyl-4-nitro-1,2-benzenediamine
N-(2-chloro-5-nitrophenyl)benzamide
6-nitro-4H-1,4-benzothiazin-3-one
4-Chloronitrobenzene
2-Chloro-5-nitrobenzenesulfonamide
5-[(2-chloro-5-nitrophenyl)amino]-2,4-dihydro-2-(2,4,6-trichlorophenyl)-3H-pyrazol-3-one

Customs

[ HS Code ]: 2921420090

[ Summary ]:
HS:2921420090 aniline derivatives and their salts VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:30.0%

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