9H-Purine,6-(propylthio)-

Suppliers

Names

[ Name ]:
9H-Purine,6-(propylthio)-

[Synonym ]:
6-propylmercapto-7(9)H-purine
6-n-propylthiopurine
6-Propyl-MP
6-Propylmercapto-7(9)H-purin
1H-Purine,6-(propylthio)
QA 71
Purine,6-(propylthio)
6-(Propylthio)purine
6-Propylmercaptopurine

Chemical & Physical Properties

[ Density]:
1.42g/cm3

[ Boiling Point ]:
315.5ºC at 760 mmHg

[ Molecular Formula ]:
C₈H₁₀N₄S

[ Molecular Weight ]:
194.25700

[ Flash Point ]:
144.6ºC

[ Exact Mass ]:
194.06300

[ PSA ]:
79.76000

[ LogP ]:
1.85500

[ Index of Refraction ]:
1.722

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UO9082000

CHEMICAL NAME :: Purine, 6-(propylthio)-

CAS REGISTRY NUMBER :: 6288-93-3

LAST UPDATED :: 198910

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C8-H10-N4-S

MOLECULAR WEIGHT :: 194.28

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 92880 ug/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Parenteral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 120 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 71,618,1982 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 100 mg/kg

SEX/DURATION :: female 7 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 4,291,1962

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intraperitoneal

DOSE :: 100 mg/kg

SEX/DURATION :: female 7-8 day(s) after conception

TOXIC EFFECTS :: Reproductive - Fertility - post-implantation mortality (e.g. dead and/or resorbed implants per total number of implants)

REFERENCE :: JRPFA4 Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- Volume(issue)/page/year: 4,291,1962

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

6-Mercaptopurine
1-Bromopropane
1-Propanethiol
6-chloropurine

DownStream

Related Compounds

9H-Purine,6-(cyclopentylthio)-
9H-Purine,6-[(2-thienylmethyl)thio]-
9H-Purine-6-carboximidamide,N-hydroxy-9-b-D-ribofuranosyl-
9H-Purine-6-carboxaldehyde,hydrazone
9H-Purine-6-thiol,2-amino-9-(6-ethyl-6-thio-b-D-ribofuranosyl)- (8CI)
9H-Purine,6-(4-morpholinyl)-9-b-D-ribofuranosyl-
2-(Ethylcarbamoyl)-5-(methoxymethyl)pyridine-3-carboxylic acid
7,7-dimethyl-2H,3H,4H,7H,8H,9H-pyrano[3,2-g]indole
Tert-butyl3-(isothiocyanatomethyl)azetidine-1-carboxylate
tert-butyl N-[(4-fluorophenyl)methyl]-N-[(2-hydroxy-1,3-benzothiazol-6-yl)methyl]carbamate
(1R)-2-amino-1-(1-cyclobutyl-1H-pyrazol-4-yl)ethan-1-ol
(1S)-2-amino-1-(1-cyclobutyl-1H-pyrazol-4-yl)ethan-1-ol
8,9-Diazatricyclo[4.3.0.0,2,4]nona-1(9),6-diene-2-carboxylic acid
4-Methyl-3-(1,4-thiazepan-4-yl)cyclohexan-1-one
4-(2-Methyl-5-oxocyclohexyl)-1lambda6-thiomorpholine-1,1-dione
3-(1,2,5-Dithiazepan-5-yl)-4-methylcyclohexan-1-one

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