N-METHYL-1,3-PROPANEDIAMINE

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Names

[ CAS No. ]:
6291-84-5

[ Name ]:
N-METHYL-1,3-PROPANEDIAMINE

[Synonym ]:
N-METHYL-1,3-PROPANEDIAMINE
MFCD00008209
1,3-Propanediamine, N-methyl-
N-methylpropane-1,3-diamine
N-Methyl-propane-1,3-diamine
N'-methylpropane-1,3-diamine
EINECS 228-544-6

Chemical & Physical Properties

[ Density]:
0.8±0.1 g/cm3

[ Boiling Point ]:
140.0±0.0 °C at 760 mmHg

[ Melting Point ]:
-72 °C

[ Molecular Formula ]:
C4H12N2

[ Molecular Weight ]:
88.151

[ Flash Point ]:
35.6±0.0 °C

[ Exact Mass ]:
88.100044

[ PSA ]:
38.05000

[ LogP ]:
-0.79

[ Vapour Pressure ]:
6.3±0.2 mmHg at 25°C

[ Index of Refraction ]:
1.431

[ Storage condition ]:
Flammables area

MSDS

Click to get detail MSDS

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TX8242500
CHEMICAL NAME :
1,3-Propanediamine, N-methyl-
CAS REGISTRY NUMBER :
6291-84-5
LAST UPDATED :
199710
DATA ITEMS CITED :
6
MOLECULAR FORMULA :
C4-H12-N2

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
951 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - hematuria
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555335
TYPE OF TEST :
LC50 - Lethal concentration, 50 percent kill
ROUTE OF EXPOSURE :
Inhalation
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
>189 mg/m3/6H
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555335
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
282 mg/kg
TOXIC EFFECTS :
Kidney, Ureter, Bladder - hematuria
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555335 ** OTHER MULTIPLE DOSE TOXICITY DATA **
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Oral
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
1300 mg/kg/13D-C
TOXIC EFFECTS :
Behavioral - food intake (animal) Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death
REFERENCE :
NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: OTS0555335

Safety Information

[ Symbol ]:

GHS02, GHS05, GHS06

[ Signal Word ]:
Danger

[ Hazard Statements ]:
H226-H302-H312-H314-H330

[ Precautionary Statements ]:
P260-P280-P284-P305 + P351 + P338-P310

[ Personal Protective Equipment ]:
Faceshields;full-face respirator (US);Gloves;Goggles;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter

[ Hazard Codes ]:
T+:Verytoxic;

[ Risk Phrases ]:
R10;R22;R26;R34

[ Safety Phrases ]:
S16-S26-S36/37-S45

[ RIDADR ]:
UN 2734 8/PG 2

[ WGK Germany ]:
3

[ RTECS ]:
TX8242500

[ Packaging Group ]:
II

[ Hazard Class ]:
8

Synthetic Route

Click to get detail synthetic route

Precursor & DownStream

Precursor

  • 3-(Methylamino)propanenitrile
  • Methanol
  • 1,3-Diaminopropane
  • 1-methyl-1-(β-cyanoethyl)hydrazine
  • Ammonia
  • 2-ethylsulfanyl-3-methyl-3H-pyrimidin-4-one
  • Ethanol

DownStream

  • n-isopropyl-1,3-propanediamine
  • tert-Butyl 3-(methylamino)propylcarbamate
  • tert-Butyl (3-aminopropyl)(methyl)carbamate
  • 1,2-Dimethyl-1,4,5,6-tetrahydropyrimidine
  • N-[3-(methylamino)propyl]oxolane-2-carboxamide
  • 1-methyltetrahydro-2(1H)-pyrimidinone(SALTDATA: FREE)
  • 2-(2-Aminoethylamino)ethanol
  • Dimethylamine
  • 1-methyl-2-phenyl-1,3,2-diazaborinane

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Methods Mol. Biol. 861 , 445-56, (2012)

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Synthesis and characterization of two aluminophosphates templated byN-methyl-1, 3-diaminopropane. Tuel A, et al.

J. Solid State Chem. 178(3) , 782-791, (2005)


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Related Compounds

  • N-cyclohexyl-N-methyl-1,3-propanediamine
  • N-Benzyl-N'-ethyl-N-methyl-1,3-propanediamine
  • N-(3-Aminopropyl)-N-methyl-1,3-propanediamine
  • N-(2-Methoxybenzyl)-N-methyl-1,3-propanediamine
  • N-(3-Methoxybenzyl)-N-methyl-1,3-propanediamine
  • N-Cyclohexyl-N'-ethyl-N-methyl-1,3-propanediamine
  • 4-((Cyclohexylamino)methyl)benzoic acid hydrochloride
  • 1-[(2,4-Dichlorophenyl)methyl]-N-(1,1-dimethylethyl)-2-methyl-1H-indole-3-methanamine
  • 2-Methoxy-6-(pyrazol-1-yl)-benzonitrile
  • 1H-3-Benzazepin-7-ol, 8-chloro-2,3,4,5-tetrahydro-5-(3-iodophenyl)-3-methyl-, (S)-
  • (4-Methyl-tetrahydro-furan-2-yl)-methanol
  • N-(1-cyanocyclopentyl)-2-[4-(4-fluorobenzenesulfonyl)-1,4-diazepan-1-yl]acetamide
  • 4,5,6,7-Tetrahydrobenzo[d]isoxazole-3-carbaldehyde
  • tert-Butyl-DL-alanine
  • 4-amino-N-[2-tert-butyl-1-(tetrahydro-2H-pyran-4-ylmethyl)-1H-benzimidazol-5-yl]-N-ethylbenzenesulfonamide
  • N-[3-(Aminooxy)propyl]-N-butyl-1-butanamine