dichlorodihydroxybis(isopropylamine)platinum

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Names

[ Name ]:
dichlorodihydroxybis(isopropylamine)platinum

[Synonym ]:
Ab-dichloro-ce-dihydroxy-df-bis(isopropylamine)platinum
PLATINUM,DICHLORODIHYDROXYBIS(2-PROPANAMINE)
Iproplatin
[Pt(IV)Cl2(OH)2(NH2-i-Pr)2]
Platinum,dichlorodihydroxybis(2-propanamine)-,(oc-6-33)
EINECS 263-762-5
cis,trans,cis-[Pt(isopropylamine)2(OH)2Cl2]
2-Propanamine,platinum complex
cis-Dichloro-trans-dihydroxy-bis(isopropylamine)platinum
JM-9
cis-dichloro-trans dihydroxy-cis-bis(isopropylamine)platinum(IV)
CHID

Chemical & Physical Properties

[ Boiling Point ]:
30.9ºC at 760 mmHg

[ Molecular Formula ]:
C₆H₂₀Cl₂N₂O₂Pt

[ Molecular Weight ]:
418.21900

[ Exact Mass ]:
417.05500

[ PSA ]:
92.50000

[ LogP ]:
3.13050

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TP2230500

CHEMICAL NAME :: Platinum(IV), bis(isopropylammine)-cis-dichloro-trans-dihydroxy-

CAS REGISTRY NUMBER :: 62928-11-4

LAST UPDATED :: 199803

DATA ITEMS CITED :: 16

MOLECULAR FORMULA :: C6-H20-Cl2-N2-O2-Pt

MOLECULAR WEIGHT :: 418.27

WISWESSER LINE NOTATION :: ZY1&1 2 &Q-PT-QGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 92 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 30 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 60 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 45 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 18 mg/kg/9W-I

TOXIC EFFECTS :: Gastrointestinal - nausea or vomiting Blood - leukopenia Blood - thrombocytopenia

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 17500 ug/kg/5D-I

TOXIC EFFECTS :: Gastrointestinal - alteration in gastric secretion Gastrointestinal - other changes

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 100 umol/L

REFERENCE :: EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 25,27,1989

Synthetic Route

Click to get detail synthetic route

Related Compounds

cis-dibromobis(isopropylamine)platinum(II)
Bis(isopropylamine)dichloroplatinum
bis-isopropylamine dinitrato platinum II
dichlorobis(isopropylamine) dihydroxyplatinum IV-hydrogen peroxide
cis-[PtI2(isopropylamine)2]
platinum(4+),propan-2-amine,propanedioate,dihydroxide
N-(4-chlorophenyl)-5-ethyl-1-methyl-4-oxo-4,5-dihydro-1H-pyrrolo[3,2-c]pyridine-2-carboxamide
3-(3-(2-chlorophenyl)-1,2,4-oxadiazol-5-yl)-1-phenylpyridazin-4(1H)-one
3-(3-(2-bromophenyl)-1,2,4-oxadiazol-5-yl)-1-phenylpyridazin-4(1H)-one
3-(4-Chlorophenyl)-5-{1-[(4-ethylphenyl)sulfonyl]pyrrolidin-2-yl}-1,2,4-oxadiazole
2-[4-(1,3-Benzodioxol-5-ylmethyl)piperazin-1-yl]-5-[(4-chlorophenyl)sulfonyl]pyrimidin-4-amine
1-Phenyl-3-{3-[3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl}-1,4-dihydropyridazin-4-one
1-phenyl-3-(3-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-5-yl)pyridazin-4(1H)-one
1-phenyl-3-(3-(pyridin-2-yl)-1,2,4-oxadiazol-5-yl)pyridazin-4(1H)-one
1-phenyl-3-(3-(pyridin-3-yl)-1,2,4-oxadiazol-5-yl)pyridazin-4(1H)-one
1-Phenyl-3-[3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl]-1,4-dihydropyridazin-4-one

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