dichlorodihydroxybis(isopropylamine)platinum

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Names

[ CAS No. ]:
62928-11-4

[ Name ]:
dichlorodihydroxybis(isopropylamine)platinum

[Synonym ]:
Ab-dichloro-ce-dihydroxy-df-bis(isopropylamine)platinum
PLATINUM,DICHLORODIHYDROXYBIS(2-PROPANAMINE)
Iproplatin
[Pt(IV)Cl2(OH)2(NH2-i-Pr)2]
Platinum,dichlorodihydroxybis(2-propanamine)-,(oc-6-33)
EINECS 263-762-5
cis,trans,cis-[Pt(isopropylamine)2(OH)2Cl2]
2-Propanamine,platinum complex
cis-Dichloro-trans-dihydroxy-bis(isopropylamine)platinum
JM-9
cis-dichloro-trans dihydroxy-cis-bis(isopropylamine)platinum(IV)
CHID

Chemical & Physical Properties

[ Boiling Point ]:
30.9ºC at 760 mmHg

[ Molecular Formula ]:
C6H20Cl2N2O2Pt

[ Molecular Weight ]:
418.21900

[ Exact Mass ]:
417.05500

[ PSA ]:
92.50000

[ LogP ]:
3.13050

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :
TP2230500
CHEMICAL NAME :
Platinum(IV), bis(isopropylammine)-cis-dichloro-trans-dihydroxy-
CAS REGISTRY NUMBER :
62928-11-4
LAST UPDATED :
199803
DATA ITEMS CITED :
16
MOLECULAR FORMULA :
C6-H20-Cl2-N2-O2-Pt
MOLECULAR WEIGHT :
418.27
WISWESSER LINE NOTATION :
ZY1&1 2 &Q-PT-QGG

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Subcutaneous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
92 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - rat
DOSE/DURATION :
30 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intraperitoneal
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
60 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
LD50 - Lethal dose, 50 percent kill
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Rodent - mouse
DOSE/DURATION :
45 mg/kg
TOXIC EFFECTS :
Details of toxic effects not reported other than lethal dose value
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
18 mg/kg/9W-I
TOXIC EFFECTS :
Gastrointestinal - nausea or vomiting Blood - leukopenia Blood - thrombocytopenia
TYPE OF TEST :
TDLo - Lowest published toxic dose
ROUTE OF EXPOSURE :
Intravenous
SPECIES OBSERVED :
Mammal - dog
DOSE/DURATION :
17500 ug/kg/5D-I
TOXIC EFFECTS :
Gastrointestinal - alteration in gastric secretion Gastrointestinal - other changes

MUTATION DATA

TYPE OF TEST :
Mutation in mammalian somatic cells
TEST SYSTEM :
Rodent - hamster Lung
DOSE/DURATION :
100 umol/L
REFERENCE :
EJCODS European Journal of Cancer and Clinical Oncology. (Pergamon Press, c/o Elsevier Science, 660 White Plains Rd., Tarrytown, NY 10591) V.17(7)- 25, 1981-89. For publisher information, see EJCAEL Volume(issue)/page/year: 25,27,1989

Synthetic Route

Click to get detail synthetic route

Related Compounds

  • cis-dibromobis(isopropylamine)platinum(II)
  • Bis(isopropylamine)dichloroplatinum
  • bis-isopropylamine dinitrato platinum II
  • dichlorobis(isopropylamine) dihydroxyplatinum IV-hydrogen peroxide
  • cis-[PtI2(isopropylamine)2]
  • platinum(4+),propan-2-amine,propanedioate,dihydroxide
  • Methyl 4-((6-benzyl-3-carbamoyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)carbamoyl)benzoate hydrochloride
  • Methyl 4-((3-carbamoyl-6-methyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)carbamoyl)benzoate hydrochloride
  • Methyl 4-((3-carbamoyl-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridin-2-yl)carbamoyl)benzoate hydrochloride
  • 2-Acetamido-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
  • 6-Methyl-2-propionamido-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
  • 6-Isopropyl-2-propionamido-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
  • 2-(2,2-dimethylpropanoylamino)-6-propan-2-yl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxamide;hydrochloride
  • 6-Benzyl-2-isobutyramido-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
  • 2-(Cyclopropanecarboxamido)-6-isopropyl-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
  • 6-Ethyl-2-(2-phenylacetamido)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide hydrochloride
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