Carbamic acid,(2-chloroethyl)nitroso-, ethyl ester (7CI,8CI,9CI)
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Names
[ CAS No. ]:
6296-45-3
[ Name ]:
Carbamic acid,(2-chloroethyl)nitroso-, ethyl ester (7CI,8CI,9CI)
[Synonym ]:
TL 154
2-Chloroethyl-N-nitrosourethane
Chemical & Physical Properties
[ Density]:
1.3g/cm3
[ Boiling Point ]:
215.4ºC at 760 mmHg
[ Molecular Formula ]:
C5H9ClN2O3
[ Molecular Weight ]:
180.59000
[ Flash Point ]:
84.1ºC
[ Exact Mass ]:
180.03000
[ PSA ]:
58.97000
[ LogP ]:
1.36510
[ Index of Refraction ]:
1.493
Toxicological Information
CHEMICAL IDENTIFICATION
- RTECS NUMBER :
- EZ2100000
- CHEMICAL NAME :
- Carbamic acid, (2-chloroethyl)nitroso-, ethyl ester
- CAS REGISTRY NUMBER :
- 6296-45-3
- BEILSTEIN REFERENCE NO. :
- 1781530
- LAST UPDATED :
- 199612
- DATA ITEMS CITED :
- 9
- MOLECULAR FORMULA :
- C5-H9-Cl-N2-O3
- MOLECULAR WEIGHT :
- 180.61
- WISWESSER LINE NOTATION :
- ON2OVM2G
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 10 mg/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - other changes Gastrointestinal - changes in structure or function of esophagus Gastrointestinal - alteration in gastric secretion
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 330 mg/m3/10M
- TOXIC EFFECTS :
- Behavioral - irritability Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6500 ug/kg
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - acute pulmonary edema Lungs, Thorax, or Respiration - pleural effusion Skin and Appendages - dermatitis, other (after systemic exposure)
- TYPE OF TEST :
- LC50 - Lethal concentration, 50 percent kill
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 75 mg/m3/10M
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 330 mg/m3/10M
- TOXIC EFFECTS :
- Behavioral - irritability Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 330 mg/m3/10M
- TOXIC EFFECTS :
- Behavioral - irritability Lungs, Thorax, or Respiration - other changes
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 6 mg/kg
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
MUTATION DATA
- TYPE OF TEST :
- DNA damage
- TEST SYSTEM :
- Rodent - mouse Leukocyte
- DOSE/DURATION :
- 500 nmol/L
- REFERENCE :
- CNREA8 Cancer Research. (Public Ledger Building, Suit 816, 6th & Chestnut Sts., Philadelphia, PA 19106) V.1- 1941- Volume(issue)/page/year: 43,175,1983